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Artikel-Nr: (BOSSBS-3414R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3414R

Beschreibung: Anti-SHC1 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3177R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3177R

Beschreibung: Anti-GAB2 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3171R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3171R

Beschreibung: Anti-HIST1H1E Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10453R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-10453R

Beschreibung: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10471R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-10471R

Beschreibung: The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-13342R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-13342R

Beschreibung: GFPT2 (glutamine-fructose-6-phosphate transaminase 2), also known as D-fructose-6-phosphate amidotransferase 2 or hexosephosphate aminotransferase 2, is a 682 amino acid protein and isoenzyme of GFAT1, the first and rate-limiting enzyme for the entry of glucose into the hexosamine biosynthetic pathway (HBP), which is a relatively minor branch of glycolysis. Expressed in spinal cord, heart and placenta, GFAT2 regulates glucose entry into the HBP and likely controls the availability of precursors for N- and O-linked protein glycosylation. Containing one glutamine amidotransferase type-2 domain and two SIS domains. GFAT2 is encoded by a gene that maps to human chromosome 5q35.3. GFAT2 gene variants have been linked to type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-11675R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11675R

Beschreibung: Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-11851R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11851R

Beschreibung: The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The Notch signaling pathway is thought to maintain stem cells through transcriptional activation of HES/HEY family members to repress tissue-specific transcription factors. HESL (HES-like), also known as Mgn or HELT (HES/HEY-like transcription factor), is a 327 amino acid nuclear protein belonging to the HEY family. Containing a basic helix-loop-helix (bHLH) domain and an Orange domain, HESL self-associates and interacts with HES5 and HRT2. HESL is considered a transcriptional repressor that binds to the canonical E box sequence 5'-CACGCG-3'. HESL exists as two isoforms produced by alternative splicing events.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-13579R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-13579R

Beschreibung: Anti-ZBTB46 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3952R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3952R

Beschreibung: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4000R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-4000R

Beschreibung: Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3956R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3956R

Beschreibung: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-15178R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15178R

Beschreibung: Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. The C3orf55 gene product has been provisionally designated C3orf55 pending further characterization.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-15181R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15181R

Beschreibung: C3orf65 (chromosome 3 open reading frame 65) is a 143 amino acid protein encoded by a gene that maps to human chromosome 3q27.2. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-15160R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15160R

Beschreibung: Anti-C2orf76 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1515R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1515R

Beschreibung: RAS superfamily comprises around 50 related genes encoding GTP-binding domain (G-proteins) involved in signal transduction. The main genes are HRAS, NRAS and KRAS. Ras proteins are membrane-bound GTPases. The inactive form is GDP-bound. They are activated by ligand-binding receptor tyrosine kinases such as EGFR, PDGFR, colony-stimulating factor and fibroblast growth factor. These kinases transiently convert RAS-GDP to RAS-GTP, the active form of RAS. Single amino acid substitutions can activate RAS making it highly oncogenic. Such mutations generally reduce the GTPase activity of RAS, prolonging it in its active GTP-bound form. The consequence of this is sustained activation of the RAF1-MAPK signalling pathway. RAS mutations are found in 10-15% of tumours. A high incidence of RAS mutations is found in pancreatic cancers.

UOM: 1 * 100 µl

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