Sie suchten nach: Biosensis

Artikel-Nr: (BSENC-1386-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1386-50

Beschreibung: Neurofilaments contain three intermediate filament proteins: light (68 kDa), medium (160 kDa) and heavy (200 kDa). Neurofilament heavy (NF200 or NF-H) is phosphorylated and it is thought that this results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. This antibody binds primarily to the phosphorylated axonal forms of NF-H.

UOM: 1 * 50 µl

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Artikel-Nr: (BSENC-1526-500)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1526-500

Beschreibung: CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

UOM: 1 * 500 µl

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Artikel-Nr: (BSENR-1685-500)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1685-500

Beschreibung: Nicastrin, a type 1 membrane glycoprotein, is an essential component of the gamma secretase complex which is critical for the cleavage of the amyloid precursor protein and other membrane proteins. Nicastrin is widely expressed in different tissue types. This antibody reacts with immature forms of Nicastrin. Detection of higher mol. wt. mature forms is likely to be blocked by glycosylation in this region of the protein.

UOM: 1 * 500 µG

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Artikel-Nr: (BSENR-1502-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1502-50

Beschreibung: Somatostatin is secreted by neuroendocrine neurons in hypothalamus and interacts with somatostatin receptors inhibiting secretion of somatotropin.

UOM: 1 * 50 µG

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Artikel-Nr: (BSENR-1500-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1500-50

Beschreibung: The hormone Atrial natriuretic peptide (ANP) is produced by cardiomyocites and is secreted into the bloodstream. ANP acts on convoluted tubules in kidney reducing sodium absorption which results in reducing the blood pressure.

UOM: 1 * 50 µG

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Artikel-Nr: (BSENM-1301-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1301-100

Beschreibung: The D-tag system utilises a short hydrophilic peptide (DYKDDDDK) that is fused to either the N- or C-terminus of the protein of interest. It can be used in conjunction with other tags such as the 6X His tag.

UOM: 1 * 100 µG

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Artikel-Nr: (BSENM-1309-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1309-100

Beschreibung: The Human influenza hemagglutin (HA) tag corresponds to a region (98-106 amino acids) from the HA molecule.

UOM: 1 * 100 µG

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Artikel-Nr: (BSENM-1306-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1306-100

Beschreibung: GST (Glutathione S-Transferase) is a 26 kDa protein encoded by the Schistosoma japonicum.

UOM: 1 * 100 µG

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Artikel-Nr: (BSENS-059-500)

Lieferant: Biosensis

Hersteller Artikel Nummer : S-059-500

Beschreibung: FUNCTION: Target-derived survival factor for peripheral sensory sympathetic neurons. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues. SIMILARITY: Belongs to the NGF-beta family.

UOM: 1 * 500 µG

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Artikel-Nr: (BSENR-102-500)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-102-500

Beschreibung: FUNCTION: Target-derived survival factor for peripheral sensory sympathetic neurons. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues. SIMILARITY: Belongs to the NGF-beta family.

UOM: 1 * 500 µG

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Artikel-Nr: (BSENR-1556-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1556-100

Beschreibung: The elF2c (Argonaute, Ago) protein is a core protein of the RNA-induced silencing complex (RISC).

UOM: 1 * 100 µl

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Lieferant: Biosensis

Beschreibung: The Biosensis NGFR/p75ECD Rapid™ enzyme-linked immunosorbent assay (ELISA) kit is a sandwich ELISA that allows the quantification of the extracellular domain (ECD) of mouse p75 neurotrophin receptor in less than 4 hours in cell culture supernatants and urine only if used as directed.

Lieferant: Biosensis

Beschreibung: The Biosensis Mouse and Rat proNGF Rapid enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the quantification of rodent full-length proNGF protein in less than 4 hours in cell culture supernatants, cell lysates and tissue homogenates only if used as directed. This ELISA Kit has also successfully been used on mouse urine samples (Ryu JC et al., 2018). Please refer to the kit protocol for specific use instructions for each substrate application.

This ELISA kit contains a recombinant mouse proNGF standard expressed in E.coli and consists of a pre-coated anti-proNGF capture antibody, a biotinylated anti-proNGF detection antibody and horseradish peroxidase (HRP)-conjugated streptavidin. The addition of a substrate (3,3',5,5'-tetramethylbenzidine, TMB) yields a colored reaction product which is directly proportional to the concentration of proNGF present in samples and protein standards. A proNGF positive control (QC sample) is provided to assure consistent assay performance. This ELISA kit detects rat proNGF due to high degree of homology (96%) with mouse proNGF based on amino acid sequence, and the ability of this kit in detecting proNGF in rat PC12 cell lysates and rat brain tissue homogenate. In the absence of a true rat proNGF standard, results may be expressed as 'mouse proNGF equivalents'. This ELISA kit shows only 20% reactivity with the human form of proNGF and is therefore not suitable to quantify human proNGF. No cross-reactivity was observed with mature mouse NGF and full-length proBDNF when tested in assay buffer.

The antibodies used in this ELISA kit bind epitopes within the pro-domain (capture) and mature domain (detection) of the protein, thus this ELISA assay does not detect the pro-domain peptide. This kit has not been tested for other applications. Sufficient amount of proNGF standard is supplied to allow for spike- and recovery experiments in order to validate this ELISA assay for other sample matrices if required.

Artikel-Nr: (BSENC-1534-500)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1534-500

Beschreibung: Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).

UOM: 1 * 500 µl

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Artikel-Nr: (BSENR-175-20)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-175-20

Beschreibung: NT3 is a member of the neurotrophin family, that controls survival and differentiation of visceral and proprioceptive sensory neurons. NT3 is closely related to both NGF and BDNF. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NT3-deficient mice generated by gene targeting display sevvere movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Brain and peripheral tissues. SIMILARITY: Belongs to the NGF-beta family.

UOM: 1 * 20 µG

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Artikel-Nr: (BSENR-1495-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1495-50

Beschreibung: Endomorphins 1 and 2 are endogenous opioid peptides which have the highest affinity for the mu-opioid receptors. Located in various parts of the brain and interacts with mu-opioid receptors and produces analgesia.

UOM: 1 * 50 µG

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