Sie suchten nach: Biosensis

Artikel-Nr: (BSENR-1491-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1491-50

Beschreibung: Adrenocorticotropic hormone (ACTH) is cleaved from the precursor pro-opiomelanocortin (POMC). The hormone is produced and secreted by the pituitary gland and stimulates release of cortisol by adrenal glands.

UOM: 1 * 50 µG

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Artikel-Nr: (BSENM-1702-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1702-100

Beschreibung: High-mobility group proteins were named originally since they are abundand relatively low molecular weight proteins which run quickly on SDS-PAGE gels. High-mobility group protein box 1 (HMGB1, Amphoterin) is one of these. The "bx" in the name refers to the so-called high mobility group (HMG) box, a compact domain involved in DNA binding and protein-protein interactions. the HMGB1 molecule has two of these HMG domains. The protein is alslo called amphoterin, this name being derived from the presence of two highly charged regions in the molecule, a relatively neutrally charged N-terminus and a very negatively charged C-terminus. In fact the molecule is very unusually charged throughout, the human sequence consisting of 16.7% Glutamic acid, 9.3% Aspartic acid, 20% lysine and 9.3% Arginine. HMGB1 can bind Toll like receptor 4 (TLR4) and the Receptor for Advanced Glycation End products (RAGE). TLRs are components of the innate immune system, first recognized as a family of receptors which recognize "Pathogen Associated Molecular Pattern molecules (PAMPs). PAMPs are common components of bacteria and when TLRs bind these a strong inflammatory response is activated. More recently it has been recognized that TLRs can also be activated by Damage Associated Molecular Pattern molecules (DAMPs), which are endogenous substances released from damaged and diseased cells which also bind to TLR family receptors and also activate inflammation. HMGB1 is such a DAMP, binding to TLR4, and much evidence suggests that HMGB1 is a strong activator of inflammation. Interestingly, HMGB1 is released by necrotic cells but not by apoptotic cells (1).

UOM: 1 * 100 µl

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Artikel-Nr: (BSENM-1300-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1300-100

Beschreibung: Recognizes native and denatured forms of Cyan Fluorescent Protein (CFP) and its variants: Enhanced Green Fluorescent Protein (EGFP), Yellow Fluorescent Protein (YFP), Enhanced Yellow Fluorescent Protein (EYFP) and Cyan Fluorescent Protein (CFP).

UOM: 1 * 100 µG

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Artikel-Nr: (BSENM-1315-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1315-100

Beschreibung: Designed to detect Red Fluorescent Protein (RFP) and its variants in ELISA (sandwich or capture), immunoblotting, immunoprecipitation and immunohistochemistry.

UOM: 1 * 100 µG

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Artikel-Nr: (BSENM-1407-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1407-100

Beschreibung: This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. The enzyme also binds to free monoubiquitin and may prevent its degradation in lysosomes (ref: SWISSPROT).

UOM: 1 * 100 µl

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Artikel-Nr: (BSENC-1393-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1393-50

Beschreibung: Neurofilaments are composed of three intermediate filament proteins: light (~68 kDa), medium (~160 kDa) and heavy (~200 kDa), which are involved in the maintenance of the neuronal caliber. Neurofilament medium runs on SDS-PAGE gels in the range 145-170 kDa, with some variation in different species.

UOM: 1 * 50 µl

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Artikel-Nr: (BSENM-1378-250)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1378-250

Beschreibung: Neurofilaments can be defined as the intermediate or 10nm diameter filaments found in neuronal cells. They are composed a mixture of subunits which often includes the neurofilament triplet proteins, NF-L, NF-M and NF-H. Neurofilaments may also include peripherin, alpha-internexin, nestin and in some cases vimentin. Alpha-internexin is a ~66 kDa Class IV intermediate filament subunit expressed in large amounts early in neuronal development, but is downregulated in many neurons as development procedes. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to alpha-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of alpha-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage.

UOM: 1 * 250 µl

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Artikel-Nr: (BSENC-1516-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1516-100

Beschreibung: Lysine acetylation of histones and non-histone proteins plays an important part in many cellular processes such as chromatin and nuclear signaling, transcription, gene silencing, cell cycle progression, apoptosis, differentiation, DNA replication and repair.

UOM: 1 * 100 µl

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Artikel-Nr: (BSENM-1384-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1384-50

Beschreibung: Myelin is a membrane characteristic of the nervous tissue and functions as an insulator to increase the velocity of the stimuli being transmitted between a nerve cell body and its target. Myelin isolated from human and bovine nervous tissue is composed of approximately 80% lipid and 20% protein, and 30% of the protein fraction constitutes myelin basic protein (MBP). MBP is an 'intrinsically unstructured' protein with a high proportion (approximately 75%) of random coil, but postulated to have core elements of beta-sheet and alpha-helix. MBP is a major protein in CNS myelin and is expressed specifically in the nervous system. A detailed immunochemical examination of monoclonal and polyclonal antibody responses to MBP and its peptides has revealed the existence of as many as 27 antigenic determinants, many of them conformational. Topological mapping of the potential antigenic determinants onto a model of MBP secondary structure places these determinants within 11 separate regions of the molecule, including those portions that have been found to be encephalitogenic. The message for myelin basic protein is selectively translocated to the ends of the cell processes. Immunization with myelin-associated antigens including MBP significantly promotes recovery after spinal cord contusion injury in the rat model. FUNCTION: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Myelin membrane; peripheral membrane protein; cytoplasmic side. Cytoplasmic side of myelin. TISSUE SPECIFICITY: Found in both the central and the peripheral nervous system.

UOM: 1 * 50 µl

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Artikel-Nr: (BSENC-1521-500)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1521-500

Beschreibung: Rod shaped photoreceptor cells that are required for image-forming vision at low light intensity and for photoreceptor cell viability after birth (ref: SWISSPROT).

UOM: 1 * 500 µl

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Artikel-Nr: (BSENC-1520-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1520-100

Beschreibung: G-Protein beta3 (GNB3) is a guanine nucleotide-binding protein (G protein). G-proteins are involved as a modulator or transducer in various transmembrane signaling systems (Ref: SWISSPROT).

UOM: 1 * 100 µl

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Artikel-Nr: (BSENR-1684-500)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1684-500

Beschreibung: Nicastrin, a type 1 membrane glycoprotein, is an essential component of the gamma secretase complex which is critical for the cleavage of the amyloid precursor protein and other membrane proteins. Nicastrin is widely expressed in different tissue types. This antibody detects all processed forms of Nicastrin.

UOM: 1 * 500 µG

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Artikel-Nr: (BSENC-1557-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1557-100

Beschreibung: Dicer is the rate limiting enzyme in the formation of mature microRNAs.

UOM: 1 * 100 µl

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Artikel-Nr: (BSENC-1538-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1538-100

Beschreibung: Peptide YY (PYY) is secreted from endocrine cells in the lower small intestine, colon and pancreas. PYY inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility (Ref: SWISS-Prot).

UOM: 1 * 100 µl

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Artikel-Nr: (BSENC-1525-200)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1525-200

Beschreibung: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) and upon binding to the receptor it induces the release of growth hormone from the pituitary. This ligand has an appetite-stimulating effect and is involved in growth regulation (Ref: SWISSPROT).

UOM: 1 * 200 µl

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Artikel-Nr: (BSENC-1540-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1540-100

Beschreibung: C-reactive protein has several roles associated with host defence such as; promoting agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. COFACTOR: Binds 2 calcium ions per subunit. C-reactive protein exists as a homopentamer. There are 2 alternatively spliced isoforms. C-reactive protein is found in plasma and its concentration increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 and IL-6.

UOM: 1 * 100 µl

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