Sie suchten nach: Biosensis

Artikel-Nr: (BSENC-1531-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1531-100

Beschreibung: FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. SUBCELLULAR LOCATION: Endoplasmic reticulum; rough endoplasmic reticulum. Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. SIMILARITY: Belongs to the orexin family.

UOM: 1 * 100 µl

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Artikel-Nr: (BSENM-1572-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1572-100

Beschreibung: 14.3.3 protein eta or 14.3.3  binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (Ref SwissProt). 14.3.3 protein eta is widely expressed as both homodimers and heterodimers and are concentrated in the nervous system. High concentrations of 14.3.3 protein eta have been linked to Creutzfeld Jacob Disease, Parkinson's Disease and early-onset schizopherenia.

UOM: 1 * 100 µG

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Artikel-Nr: (BSENC-1409-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1409-50

Beschreibung: Vimentins are class-III intermediate filaments specific to mesenchymal tissue. Vimentin is an important cytoskeletal component responsible for maintaining cell integrity and has a probable role in the intracellular transport of proteins such as lipoproteins between the nucleus and plasma membrane. Immunohistochemical staining for Vimentin is characteristic of sarcomas. 

UOM: 1 * 50 µl

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Artikel-Nr: (BSENM-1391-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1391-50

Beschreibung: Neurofilaments are composed of three intermediate filament proteins: light (~68 kDa), medium (~160 kDa) and heavy (~200 kDa), which are involved in the maintenance of the neuronal caliber. Neurofilament light (NF68 or NF-L) is the most abundant of the three proteins.

UOM: 1 * 50 µl

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Artikel-Nr: (BSENM-1325-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1325-100

Beschreibung: Clone OX-42 recognises the rat equivalent of human CD11b. CD11b is a single-pass type I membrane protein that belongs to the integrin alpha chain family. CD11b is predominantly expressed in monocytes and granulocytes and is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles (Ref: SWISSPROT). CD11b is also frequently used as a microglial marker allowing to distinguish between quiescent and activated microglia based on the intensity of CD11b staining.

UOM: 1 * 100 µG

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Artikel-Nr: (BSENM-1376-250)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1376-250

Beschreibung: Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a metabolic enzyme responsible for catalyzing one step in the glycolytic pathway, the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate. GAPDH may have other roles in the activation of transcription and in the regulation of apoptosis as well as Alzheimer's disease and Huntington's disease. The immunogen used to raise this particular antibody was extensively purified pig GAPDH. This antibody can be used as a loading control for western blotting experiments, allowing comparison between the level of this protein and others in a cell or tissue.

UOM: 1 * 250 µl

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Artikel-Nr: (BSENS-051-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : S-051-50

Beschreibung: FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons. SUBUNIT: Homodimer, associated by noncovalent forces. SUBCELLULAR LOCATION: Secreted protein. SIMILARITY: Belongs to the NGF-beta family.

UOM: 1 * 50 µG

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Artikel-Nr: (BSENR-1683-500)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1683-500

Beschreibung: Beta-synuclein is a soluble cytoplasmic protein associated with synaptic vesicles and a member of the synuclein family. Mutations in alpha-synuclein cause early onset Parkinson's disease. Expression of beta synuclein may modulate alpha-synuclein aggregation found in Parkinson's disease.

UOM: 1 * 500 µG

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Artikel-Nr: (BSENR-1621-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1621-100

Beschreibung: This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]

UOM: 1 * 100 µG

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Artikel-Nr: (BSENR-1680-500)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1680-500

Beschreibung: Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).

UOM: 1 * 500 µG

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Artikel-Nr: (BSENR-1547-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1547-100

Beschreibung: Lysine acetylation of histones and non-histone proteins plays an important part in many cellular processes such as chromatin and nuclear signaling, transcription, gene silencing, cell cycle progression, apoptosis, differentiation, DNA replication and repair.

UOM: 1 * 100 µl

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Artikel-Nr: (BSENM-1725-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1725-100

Beschreibung: MAP1A and MAP1B are microtubule-associated protein which mediate the physical interactions between microtubules and components of the cytoskeleton (probably involved in autophagosome formation). MAP1A and MAP1B each consist of a heavy chain subunit and 3 different light chain subunits (LC1, LC2 and LC3). MAP1LC3A is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor form of MAP1LC3A is cleaved by APG4/ATG4B to form the cytosolic form LC3-1. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. MAP1LC3A is most abundant in heart, brain, liver, skeletal muscle and testis but is absent in thymus and peripheral leukocytes.

UOM: 1 * 100 µG

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Artikel-Nr: (BSENR-1751-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1751-50

Beschreibung: This antibody is a nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling.

UOM: 1 * 50 µG

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Artikel-Nr: (BSENR-1684-500)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1684-500

Beschreibung: Nicastrin, a type 1 membrane glycoprotein, is an essential component of the gamma secretase complex which is critical for the cleavage of the amyloid precursor protein and other membrane proteins. Nicastrin is widely expressed in different tissue types. This antibody detects all processed forms of Nicastrin.

UOM: 1 * 500 µG

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Artikel-Nr: (BSENM-1407-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : M-1407-100

Beschreibung: This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. The enzyme also binds to free monoubiquitin and may prevent its degradation in lysosomes (ref: SWISSPROT).

UOM: 1 * 100 µl

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Artikel-Nr: (BSENC-1393-50)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1393-50

Beschreibung: Neurofilaments are composed of three intermediate filament proteins: light (~68 kDa), medium (~160 kDa) and heavy (~200 kDa), which are involved in the maintenance of the neuronal caliber. Neurofilament medium runs on SDS-PAGE gels in the range 145-170 kDa, with some variation in different species.

UOM: 1 * 50 µl

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