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Artikel-Nr: (ABFRLF-PA0011)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-PA0011

Beschreibung: Anti-Peroxiredoxin 6 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (ABFRLF-PA0228)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-PA0228

Beschreibung: Anti-Alpha/ Beta-Synuclein Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (ABFRLF-PA0173)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-PA0173

Beschreibung: Anti-IRAK4 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (ABFRLF-MA0173)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-MA0173

Beschreibung: The Rb protein (pRb, 110kDa) is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. pRb is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. pRb prevents the cell from replicating damaged DNA by preventing its progression through the cell cycle into its S phase or progressing through G1 phase. pRb can actively inhibit cell cycle progression when it is dephosphorylated while this function is inactivated when pRb is phosphorylated. pRb is activated near the end of mitosis (M phase) when a phosphatase dephosphorylates it, allowing it to bind E2F. The pRb protein represses gene transcription, required for transition from G1 to S phase, by directly binding to the transactivation domain of E2F and by binding to the promoter of these genes as a complex with E2F.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-MA0174)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-MA0174

Beschreibung: Transthyretin (TTR, 55 kDa homotetramer) is a thyroid hormone-binding protein that transports thyroxine (T4) from the bloodstream to the brain. TTR was originally called prealbumin because it ran faster than albumin on electrophoresis gels. . TTR is produced in the liver and circulates in the bloodstream, where it binds retinol and thyroxine. TTR is suggested that plays an essential role in brain function. The protein consists of around 130 amino acids, which assemble as a homotetramer that contains an internal channel in which T4 is bound. Within this complex, T4 appears to be transported across the blood-brain barrier, where, in the choroid plexus, the hormone stimulates further synthesis of transthyretin. The protein then diffuses back into the bloodstream, where it binds T4 for transport back to the brain. TTR is known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC).

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-MA0186)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-MA0186

Beschreibung: SHP2 is a tyrosine phosphatase containing two tandem SH2 (src homology 2) domains. Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signaling molecules.
SHP1 and SHP2 represent a subfamily of non-transmembrane PTPs that contain two SH2 domains followed by a PTP domain. Tyrosine phosphorylation of SHP2 is required for normal ERK activation in response to some growth factors. In the inactive state, the N-terminal SH2 domain binds the PTP domain and blocks access of potential substrates to the active site. This auto-inhibition is relieved by the binding of phosphopeptides to SH2 domain, resulting in activation of phostphatase activity.
Noonan syndrome characterized by an abnormal face, short stature and cardiac abnormalities is due to the mutations of N-terminal SH2 domain or PTP domain. SHP2 mutations might also cause some leukemia, and could be important in pathogenesis by Helicobacter pylori, the major cause of gastric ulcer and carcinoma.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-MA0167)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-MA0167

Beschreibung: α-1-Acid glycoprotein (AGP) is a protein with a molecular weight of 41~43 kDa and is heavily glycosylated (45%). Due to the presence of sialic acids, it is negatively charged (pI=2.7-3.2). AGP is one of the major acute phase proteins in humans. As most acute phase proteins, its serum concentration increases in response to systemic tissue injury, inflammation or infection, and these changes in serum protein concentrations have been correlated with increases in hepatic synthesis. Also, its glycosylation pattern can change depending on the type of inflammation. The biological function of AGP remains unknown; however, AGP is believed to regulate the interaction between blood cells and endothelial cells, and regulates the extravasation of the cells during infection and inflammation.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-MA0172)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-MA0172

Beschreibung: The Rb protein (pRb, 110kDa) is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. pRb is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. pRb prevents the cell from replicating damaged DNA by preventing its progression through the cell cycle into its S phase or progressing through G1 phase. pRb can actively inhibit cell cycle progression when it is dephosphorylated while this function is inactivated when pRb is phosphorylated. pRb is activated near the end of mitosis (M phase) when a phosphatase dephosphorylates it, allowing it to bind E2F. The pRb protein represses gene transcription, required for transition from G1 to S phase, by directly binding to the transactivation domain of E2F and by binding to the promoter of these genes as a complex with E2F.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-MA0184)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-MA0184

Beschreibung: The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and β-cells.
Recent integrative genomic analyses on HES/HEY family suggest that HES1 and HES3 are target genes of the embryonic stem cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL are target genes of Notch signaling pathway.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-PA0183)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-PA0183

Beschreibung: Sequential activation of protein kinases within the MAPK (mitogen-activated protein kinases) cascades is a common mechanism of signal transduction in many cellular processes. The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of various cellular processes such as proliferation, differentiation, development, learning, and survival. Mitogen-activated protein kinase kinases (MAPKK) phosphorylate MAPK. MEK (MAP kinase or ERK kinase) is the immediate upstream activator kinase of ERK.
MEK6 encodes a 334-amino acid protein with 82% identity to MKK3. MEK6 is highly expressed in skeletal muscle like many other members of this family, but in contrast to MKK3 its expression in leukocytes is very low. The human MEKs (MEK1, MEK2, MEK3) show remarkably different activity toward ERKl and ERK2. MEK2 is the most active ERK activator. MEK3 is inactive toward ERKl or ERK2. MEK3, MEK4, and MEK6 phosphorylate and activate p38 MAP kinase. The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by proinflammatory cytokines and environmental stress. Transcription factors such as ATF2 and Elk-1 are targets of the p38 MAP kinase signal transduction pathway.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-PA0062)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-PA0062

Beschreibung: NF-κB (Nuclear Factor kappa B) is a nuclear transcription factor found in all cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Consistent with this role, incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection and improper immune development. There are five members in the NF-κB family: NF-κB1, NF-κB2, RelA (also named p65), RelB, and c-Rel. RelA(p65) subunit of NF-κB is a crucial regulator of apoptosis. RelA subunit mediates resistance to programmed cell death induced by many stimuli, including TNF, chemotherapy agents and ionizing radiation, through inducing the expression of a wide variety of anti-apoptotic genes.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-PA0193)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-PA0193

Beschreibung: The casein kinase I (CKI) family of serine/threonine protein kinases is highly conserved from yeast to humans. The CKI family is involved in many diverse and important cellular functions, such as regulation of membrane transport, cell division, DNA repair, circadian rhythms, and nuclear localization.
The name of the enzyme family was originated from the convenience of casein as a substrate since the earliest days of research on protein phosphorylation.
Casein kinase 2 (CK2) is a ubiquitous, highly conserved, essential serine/threonine kinase which has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.
CK2 is a tetramer of two α subunits and two β subunits. The α subunits have the catalytic kinase domain. Loss of the α‘ catalytic subunit produces male infertility, and loss of the single β regulatory subunit is
early embryonic lethal.
CK2 appears to be upregulated in most cancers and the promotion of tumorigenesis by the overexpression of CK2 has been reported in transgenic mice.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-PA0195)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-PA0195

Beschreibung: RAF is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. The mammalian Raf family of serine/threonine kinases consists of three highly conserved members: A-Raf, B-Raf, and Raf-1 (or c-Raf-1). Each isoform has three conserved regions in common: CR1, CR2, and CR3. Raf isoforms vary in their cell-specific expression and potency of kinase activity. Cytosolic C-Raf ubiquitously expressed in adult tissues, with highest expression in muscle, cerebellum, and fetal brain. Activation of c-Raf is the best understood and involves phosphorylation at multiple activating sites. Six residues of c-Raf (Ser29, Ser43, Ser289, Ser296, Ser301 and Ser642) become hyperphosphorylated in a manner consistent with c-Raf inactivation. The hyperphosphorylation of these six sites is dependent on downstream MEK signaling and renders c-Raf unresponsive to subsequent activation events.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-PA0049)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-PA0049

Beschreibung: ROCK, Rho-associated coiled-coil forming kinases, is a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. ROCK, as a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. ROCK2 regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-PA0025)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-PA0025

Beschreibung: Histone H2A is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. The nucleosome in which an 147 base-pairs of DNA are wrapped 1.7 times around a central core of eight histone protein molecules forms the basic building block of chromatin. Histone octamer consists of two copies each of H2A, H2B, H3, and H4 histones.
Histone H2A variant H2AX, a component of the nucleosome core structure that comprises 10%–15% of total cellular H2A, has a special role in DNA repair, cell cycle checkpoints, regulated gene recombination events, and tumor suppression.
H2AX can be phosphorylated on Ser 1, acetylated on Lys 5 and ubiquitinated on Lys 119. But what makes H2AX unique is a highly conserved serine 139 residue which is rapidly phosphorylated upon the exposure of cells to DNA damage. H2AX is phosphorylated by ATR in response to DNA replication stress, and primarily by ATM in response to low levels of ionizing radiation. Phosphorylation of H2AX increases the likelihood of assembling a functional repair complex by increasing the local concentration of repair factors near the lesion.

UOM: 1 * 0,1 mL

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Artikel-Nr: (ABFRLF-PA0058)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-PA0058

Beschreibung: The inhibitor of caspase-3-activated DNase (ICAD) is a caspase-3 substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of M.W. 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a M.W.35kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD. In addition to its DNase inhibitory activity, ICAD acts as a CAD-specific folding chaperone. There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells.

UOM: 1 * 0,1 mL

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