Anti-DFFA Rabbit Polyclonal Antibody

Lieferant: AbFrontier
LF-PA0058
ABFRLF-PA0058EA 311 CHF
ABFRLF-PA0058
Anti-DFFA Rabbit Polyclonal Antibody
Antikörper
The inhibitor of caspase-3-activated DNase (ICAD) is a caspase-3 substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of M.W. 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a M.W.35kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complexMore Product Information
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