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Artikel-Nr: (BOSSBS-2162R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-2162R-A750

Beschreibung: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalisation of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-0112M-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-0112M-A750

Beschreibung: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5733R-A680)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-5733R-A680

Beschreibung: Adapter protein involved in asymmetrical cell division and cell polarisation processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5733R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-5733R-HRP

Beschreibung: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5734R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-5734R-HRP

Beschreibung: PCGF1 is a component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. It represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). PCGF1 als promotes cell cycle progression and also enhances cell proliferation, thus it may have a positive role in tumor cell growth.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5733R-FITC)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-5733R-FITC

Beschreibung: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1764R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1764R-A555

Beschreibung: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-13034R-FITC)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-13034R-FITC

Beschreibung: DTYMK is a 212 amino acid protein that belongs to the thymidylate kinase family and is involved in pyrimidine metabolism. Specifically, DTYMK catalyzes the ATP-dependent conversion of dTMP (deoxythymidine monophosphate) to dTDP (deoxythymidine diphosphate), which then functions as one of the four nucleotides in DNA. Via its role in the catalytic creation of dTDP, DTYMK plays an important role in the pathway of DNA synthesis and is thought to be involved in cell cycle progression and cell growth. DTYMK expression levels peak during the S phase (synthesis phase) of the cell cycle, further supporting the role of DTYMK in DNA synthesis.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6478R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-6478R-A555

Beschreibung: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-0931R-CY7)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-0931R-CY7

Beschreibung: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-2777R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-2777R-HRP

Beschreibung: Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV42H1 and SUV42H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-2' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV4 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1427R-A647)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1427R-A647

Beschreibung: IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1427R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1427R-A555

Beschreibung: IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-14278R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-14278R-A750

Beschreibung: GTPase activator activity.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-0203R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-0203R-HRP

Beschreibung: Angiotensin I converting Enzyme Inhibitor, ACEI also designated Bradykinin-potentiating peptide. The peptide: PTHIKWGD. Processed active peptide.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-13271R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-13271R-A555

Beschreibung: The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T11 (Polypeptide N-acetylgalactosaminyltransferase 11), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11, is a 608 amino acid protein that catalyzes glycosylation of Muc1, Muc4.1 and EA2, though it does not display enzymatic preference for erythropoitein. The N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding and catalytic reaction. GalNAc-T11 is highly expressed in kidney tubules, though it is not expressed in glomeruli. There are two isoforms of GalNAc-T11 that are produced as a result of alternative splicing events.

UOM: 1 * 100 µl

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