Sie suchten nach: Bioss

Artikel-Nr: (BOSSBS-15222R-A350)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15222R-A350

Beschreibung: Making up nearly 6% of the human genome, chromosome 6 contains around 1200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf145 gene product has been provisionally designated C6orf145 pending further characterisation.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3405R-A680)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3405R-A680

Beschreibung: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-15223R-A350)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15223R-A350

Beschreibung: Making up nearly 6% of the human genome, chromosome 6 contains around 1200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf146 gene product has been provisionally designated C6orf146 pending further characterisation.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3405R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3405R-HRP

Beschreibung: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7083R-A647)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7083R-A647

Beschreibung: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3406R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3406R-A555

Beschreibung: Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes and can lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. A number of cellular factors interact with hSMC1/hSMC3 during cell cycle. The major population of hSMC1/hSMC3 is in a compex with hRAD21 forming the human cohesion complex. Human cohesion complex associates with chromosomes which peaks at S phase and dissociates from chromosomes during G2/M transition. In addition, a subpopulation of hSMC1/hSMC3 associates tightly with nuclear matrix and centrosomes during interphase. A subset of hSMC1/hSMC3 is localized to spindle poles, spindles and kinetochores during mitosis when cohesin is in the cytoplasm. hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus protein in vivo.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3088R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3088R-A750

Beschreibung: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10462R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-10462R-CY3

Beschreibung: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6385R-CY5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-6385R-CY5

Beschreibung: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6385R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-6385R-CY3

Beschreibung: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3037R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3037R-A750

Beschreibung: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3127R-CY5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3127R-CY5

Beschreibung: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9405R-FITC)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-9405R-FITC

Beschreibung: CC85C

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9405R-A647)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-9405R-A647

Beschreibung: CC85C

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1233R-A488)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1233R-A488

Beschreibung: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9741R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-9741R-A750

Beschreibung: ANGEL1, also known as KIAA0759, is a 670 amino acid protein belonging to the CKR-4 protein family. ANGEL1 is encoded by a gene located on human chromosome 14, which contains about 700 genes and 106 million base pairs, making up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterised by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus on chromosome 14 and its fusion via translocation with the chromosome 19 encoded protein BCL3 may be related to B-cell malignancies.

UOM: 1 * 100 µl

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