Sie suchten nach: Methyl trans-3-hydroxycyclobutanecarboxylate

Beschreibung: This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. Epitope of this MAb is mapped between aa300-550. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.

Artikel-Nr: BTIUBNC040420-500

UOM: 1 * 500 µl

Hersteller Artikel Nummer : BNC040420-500

Lieferant: Biotium

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Beschreibung: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

Artikel-Nr: BNCB0084-100

UOM: 1 * 100 µl

Hersteller Artikel Nummer : BNCB0084-100

Lieferant: Biotium

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Beschreibung: This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. Epitope of this MAb is mapped between aa300-550. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.

Artikel-Nr: BTIUBNC680420-500

UOM: 1 * 500 µl

Hersteller Artikel Nummer : BNC680420-500

Lieferant: Biotium

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Beschreibung: Anti-IgG2a Goat Polyclonal Antibody (CF™ 640R)

Artikel-Nr: 20261-1

UOM: 1 * 50 µl

Hersteller Artikel Nummer : 20261-1

Lieferant: Biotium

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Beschreibung: Anti-IgG Rabbit Polyclonal Antibody (CF™ 770)

Artikel-Nr: 20244.

UOM: 1 * 0,5 mL

Hersteller Artikel Nummer : 20244

Lieferant: Biotium

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Beschreibung: Anti-IgG Goat Polyclonal Antibody (CF™ 543)

Artikel-Nr: 20328-1

UOM: 1 * 50 µl

Hersteller Artikel Nummer : 20328-1

Lieferant: Biotium

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Beschreibung: Anti-IgG2a Goat Polyclonal Antibody (CF™ 594)

Artikel-Nr: 20259-1

UOM: 1 * 50 µl

Hersteller Artikel Nummer : 20259-1

Lieferant: Biotium

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Beschreibung: Anti-Fluorescein Mouse Monoclonal Antibody (FITC (Fluorescein))

Artikel-Nr: 20210.

UOM: 1 * 0,25 mL

Hersteller Artikel Nummer : 20210

Lieferant: Biotium

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Beschreibung: Anti-Fluorescein Mouse Monoclonal Antibody (FITC (Fluorescein))

Artikel-Nr: 20214.

UOM: 1 * 0,25 mL

Hersteller Artikel Nummer : 20214

Lieferant: Biotium

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Beschreibung: Anti-Fluorescein Mouse Monoclonal Antibody (FITC (Fluorescein))

Artikel-Nr: 20212.

UOM: 1 * 0,25 mL

Hersteller Artikel Nummer : 20212

Lieferant: Biotium

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Beschreibung: Anti-GFP Mouse Monoclonal Antibody (CF®640R)

Artikel-Nr: 20218.

UOM: 1 * 0,1 mL

Hersteller Artikel Nummer : 20218

Lieferant: Biotium

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Beschreibung: Anti-IgG Goat Polyclonal Antibody (CF™ 594)

Artikel-Nr: 20303-1

UOM: 1 * 50 µl

Hersteller Artikel Nummer : 20303-1

Lieferant: Biotium

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Beschreibung: CF™543 antibodies are affinity-purified antibodies labeled with orange fluorescent CF™543 (Ex/Em 541/560nm), a member of the novel CF™ dye series developed by Biotium for labeling proteins and other biomolecules. CF™ dyes are designed to offer advantages in brightness, photostability, and/or specificity compared to other commercial dyes, and are available in colors spanning the visible, far-red, and near-infrared spectra.

Artikel-Nr: 20334-500UL

UOM: 1 * 0,5 mL

Hersteller Artikel Nummer : 20334-500UL

Lieferant: Biotium

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Beschreibung: CF™543 antibodies are affinity-purified antibodies labeled with orange fluorescent CF™543 (Ex/Em 541/560nm), a member of the novel CF™ dye series developed by Biotium for labeling proteins and other biomolecules. CF™ dyes are designed to offer advantages in brightness, photostability, and/or specificity compared to other commercial dyes, and are available in colors spanning the visible, far-red, and near-infrared spectra.

Artikel-Nr: 20334-50UL

UOM: 1 * 50 µl

Hersteller Artikel Nummer : 20334-50UL

Lieferant: Biotium

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Beschreibung: CF™488A antibodies are affinity-purified antibodies labeled with green fluorescent CF™488A, a member of the novel CF™ dye series developed by Biotium for labeling proteins and other biomolecules. CF™ dyes are designed to offer advantages in brightness, photostability, and/or specificity compared to other commercial dyes, and are available in colors spanning the visible, far-red, and near-infrared spectra.

Artikel-Nr: 20347-50UL

UOM: 1 * 50 µl

Hersteller Artikel Nummer : 20347-50UL

Lieferant: Biotium

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Beschreibung: CF™568 antibodies are affinity-purified antibodies labeled with red fluorescent CF™568, a member of the novel CF™ dye series developed by Biotium for labeling proteins and other biomolecules. CF™ dyes are designed to offer advantages in brightness, photostability, and/or specificity compared to other commercial dyes, and are available in colors spanning the visible, far-red, and near-infrared spectra.

Artikel-Nr: 20337-50UL

UOM: 1 * 50 µl

Hersteller Artikel Nummer : 20337-50UL

Lieferant: Biotium

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