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Image Unavailable-BOSSBS-2162R-A350

Anti-DKK1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Beschreibung: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Artikel-Nr: BOSSBS-2162R-A350
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-2162R-A350
Lieferant: Bioss
Image Unavailable-BOSSBS-2162R-A488

Anti-DKK1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Beschreibung: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Artikel-Nr: BOSSBS-2162R-A488
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-2162R-A488
Lieferant: Bioss
Image Unavailable-BOSSBS-7877R-A555

Anti-NEDD4 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Beschreibung: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
Artikel-Nr: BOSSBS-7877R-A555
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-7877R-A555
Lieferant: Bioss
Image Unavailable-BOSSBS-5883R

Anti-SLC9A3R1 Rabbit Polyclonal Antibody

Beschreibung: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
Artikel-Nr: BOSSBS-5883R
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-5883R
Lieferant: Bioss
Image Unavailable-BOSSBS-6672R-A488

Anti-KCNJ3 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Beschreibung: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Artikel-Nr: BOSSBS-6672R-A488
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-6672R-A488
Lieferant: Bioss
Image Unavailable-BOSSBS-3299R-CY3

Anti-NEDD4L Rabbit Polyclonal Antibody (Cy3®)

Beschreibung: E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.
Artikel-Nr: BOSSBS-3299R-CY3
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-3299R-CY3
Lieferant: Bioss
Image Unavailable-BOSSBS-3299R-A488

Anti-NEDD4L Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Beschreibung: E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.
Artikel-Nr: BOSSBS-3299R-A488
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-3299R-A488
Lieferant: Bioss
Image Unavailable-ICNA0210098110

5-Phospho-D-ribose 1-diphosphate pentasodium salt, weißes Pulver

Beschreibung: 5-Phosphorylribose-1-pyrophosphate Sodium Salt Hydrate has been used in a study to assess the relationship between the muscarinic receptor cationic current and internal calcium in guinea-pig jejunal smooth muscle cells. It has also been used in a study to investigate inhibitors of the bacterial cell wall biosynthesis of the enzyme Mur D.
Artikel-Nr: ICNA0210098110
UOM: 1 * 10 mg
Hersteller Artikel Nummer : 0210098110
Lieferant: MP Biomedicals
Image Unavailable-BOSSBS-3299R-A680

Anti-NEDD4L Ser342 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Beschreibung: E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.
Artikel-Nr: BOSSBS-3299R-A680
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-3299R-A680
Lieferant: Bioss
Image Unavailable-ORIGCF811858

Anti-MRC2 Mouse Monoclonal Antibody [clone: OTI9G4]

Beschreibung: This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease.
Artikel-Nr: ORIGCF811858
UOM: 1 * 100 µG
Hersteller Artikel Nummer : CF811858
Lieferant: OriGene
Image Unavailable-BOSSBS-13164R-A647

Anti-FLNA Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Beschreibung: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
Artikel-Nr: BOSSBS-13164R-A647
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-13164R-A647
Lieferant: Bioss
Image Unavailable-BOSSBS-13164R-FITC

Anti-FLNA Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Beschreibung: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
Artikel-Nr: BOSSBS-13164R-FITC
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-13164R-FITC
Lieferant: Bioss
Image Unavailable-BOSSBS-13164R-A488

Anti-FLNA Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Beschreibung: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
Artikel-Nr: BOSSBS-13164R-A488
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-13164R-A488
Lieferant: Bioss
Image Unavailable-BOSSBS-7877R-HRP

Anti-NEDD4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Beschreibung: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
Artikel-Nr: BOSSBS-7877R-HRP
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-7877R-HRP
Lieferant: Bioss
Image Unavailable-BOSSBS-6468R-A647

Anti-KCNJ8 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Beschreibung: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).
Artikel-Nr: BOSSBS-6468R-A647
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-6468R-A647
Lieferant: Bioss
Image Unavailable-BOSSBS-6468R-A680

Anti-kir 6.1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Beschreibung: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterised by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).
Artikel-Nr: BOSSBS-6468R-A680
UOM: 1 * 100 µl
Hersteller Artikel Nummer : BS-6468R-A680
Lieferant: Bioss
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