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Beschreibung: The 90 kDa molecular chaperone family includes 90 kDa heat shock protein Hsp90 and 94 kDa glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum. Mammalian cells contain isoforms Hsp90 alpha and Hsp90 beta, encoded by separate genes. The amino acid sequences of human and yeast Hsp90 alpha are 85% and 90% homologous to those of Hsp90 beta, respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N -terminal and C-terminal regions containing independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 functions as part of the cell

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Lieferant: ENZO LIFE SCIENCES

Beschreibung: The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

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Artikel-Nr: (ENZOBMLFG60200100)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : BMLFG60200100

Beschreibung: Fibronectins are high molecular weight, disulphide-linked, dimeric cell adhesion glycoproteins found in basement membranes and in the interstitial connective tissue matrix. A single fibronectin gene is subject to alternative splicing in a cell-type-, development- and age-regulated manner which gives rise to multiple molecular forms. In addition to their prominent role in adhesion, fibronectins have been reported to mediate various aspects of cellular interaction, including migration during development and wound-healing, haemostasis, and the regulation of cell growth and differentiation. Cellular fibronectins (cFn) are found in low amounts in normal human plasma and tissues, but they are abundant in the plasma of carcinoma patients and in the stroma of various carcinomas. In contrast, a soluble form of fibronectin produced by hepatocytes is readily detectable in plasma and becomes deposited in pericellular matrices and within tissues. This form of fibronectin, referred to as ‘plasma fibronectin’ (pFn), differs from cFn by the absence of an amino acid sequence, known as extra domain A1.

UOM: 1 * 100 µl

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Artikel-Nr: (ENZOALX802009R100)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX802009R100

Beschreibung: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µl

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Artikel-Nr: (ENZOALX8010901)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX8010901

Beschreibung: Host: Mouse, Isotype: IgM

UOM: 1 * 1 Vial

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Artikel-Nr: (ENZOALX804022R100)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX804022R100

Beschreibung: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µl

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Artikel-Nr: (ENZOALX803004C050)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX803004C050

Beschreibung: Steroid receptors are a large superfamily of ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Estrogen receptor (ER) has been classified into two distinct isoforms, α and β. ERα is known to interact in a ligand dependent and independent manner with several known coactivators including Receptor-Interacting Protein 140 (RIP140/ERAP140), ERAP160, and Steroid Receptor Coactivator-1 (SRC-1) to enhance transcriptional activity of target genes.

UOM: 1 * 50 µG

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Artikel-Nr: (ENZOALX803309R100)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX803309R100

Beschreibung: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µl

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Artikel-Nr: (ENZOALX801089C100)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX801089C100

Beschreibung: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Artikel-Nr: (ENZOALX804071R100)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX804071R100

Beschreibung: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µl

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Artikel-Nr: (ENZOALX804079R400)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX804079R400

Beschreibung: Host: Mouse, Isotype: IgM

UOM: 1 * 400 µl

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Artikel-Nr: (ENZOBPDABS048281)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : BPDABS048281

Beschreibung: Anti-NGAL Mouse Monoclonal Antibody [clone: 28]

UOM: 1 * 1 mg

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Artikel-Nr: (ENZOBPDABS058081)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : BPDABS058081

Beschreibung: Anti-GCG Mouse Monoclonal Antibody [clone: 8]

UOM: 1 * 1 mg

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Artikel-Nr: (ENZOALX805083C100)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX805083C100

Beschreibung: The normal cross-reacting antigen (NCA) or CEACAM6 belongs to the carcinoembryonic antigen (CEA) gene family. CEACAM6 is a GPI-anchored membrane protein with a single N domain, which shows structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like domains.

UOM: 1 * 100 µG

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Artikel-Nr: (ENZOALX810410L015)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX810410L015

Beschreibung: Host: Rabbit, Isotype: IgG

UOM: 1 * 15 mL

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Artikel-Nr: (ENZOADIKAPGP126D)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ADIKAPGP126D

Beschreibung: The Ras superfamily of small guanosine triphosphatases (GTPases) is traditionally subdivided into five families: Ras, Rho, Rab, Ran, and Arf. Rap1/Krev1 is a member of the Ras family of low molecular weight GTP-binding proteins1. Ras-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches that couple extracellular signals to various cellular responses. Rap1 is primarily found at the cytosolic side of intracellular membranes and has two isoforms: Rap1a and 1b2. Both isoforms have a molecular mass of 21 kDa and are isoprenylated at the carboxyl-terminal and phosphorylated by the cAMP-dependent protein kinase A (PKA)3. Rap1 cycles between a GTP-bound active form and a GDP-bound inactive form that is mediated by GTPase activating protein (GAP) and GDP dissociation stimulator (GDS)4,5. Activation occurs by a variety of extracellular stimuli through several conserved guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 is proposed to regulate Ras mediated signaling and may also be involved in the regulation of integrinmediated cell adhesion, although the mechanism of regulation is not known. Overexpression of Rap reverses the transformed phenotype induced by Ras, possibly by competing with Ras for interaction with Ras-GAP. Rap has been shown to participate in MAP kinase cascade activated by growth factor and maintaining human T cell anergic state by blocking IL-2 expression.

UOM: 1 * 50 µG

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