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Anti-PNPO Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI27-181)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 27-181

Beschreibung: PNPO catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine.Vitamin B6, or pyridoxal 5-prime-phosphate (PLP), is critical for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. The rate-limiting enzyme in vitamin B6 synthesis is pyridoxine-5-prime-phosphate (PNP) oxidase (PNPO; EC 1.4.3.5).

UOM: 1 * 50 µG

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Anti-GLRX5 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI27-103)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 27-103

Beschreibung: Defects in GLRX5 are the cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA). The specific function of GLRX5 is not yet known.

UOM: 1 * 50 µG

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Anti-GAD1 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI55-719)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 55-719

Beschreibung: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

UOM: 1 * 400 µl

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