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Anti-AGP Mouse Monoclonal Antibody [clone: 27A1]

Artikel-Nr: (ABFRLF-MA0167)

Lieferant: AbFrontier

Hersteller Artikel Nummer : LF-MA0167

Beschreibung: α-1-Acid glycoprotein (AGP) is a protein with a molecular weight of 41~43 kDa and is heavily glycosylated (45%). Due to the presence of sialic acids, it is negatively charged (pI=2.7-3.2). AGP is one of the major acute phase proteins in humans. As most acute phase proteins, its serum concentration increases in response to systemic tissue injury, inflammation or infection, and these changes in serum protein concentrations have been correlated with increases in hepatic synthesis. Also, its glycosylation pattern can change depending on the type of inflammation. The biological function of AGP remains unknown; however, AGP is believed to regulate the interaction between blood cells and endothelial cells, and regulates the extravasation of the cells during infection and inflammation.

UOM: 1 * 0,1 mL

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2-Brom-4,5-dichlorimidazol

Lieferant: Apollo Scientific

Beschreibung: 2-Brom-4,5-dichlorimidazol

WYE-125132 ≥98%, kristalliner Feststoff

Lieferant: Cayman Chemical

Beschreibung: WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.