Staurosporine ≥98% (durch HPLC)
Lieferant: ENZO LIFE SCIENCES
Synonyms:
(5S,6R,7R,9R)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one, Antibiotic AM-2282
Apoptosis inducer.
- Protein kinase inhibitor
- Isolated from Streptomyces staurosporeus
- Off-white to green powder
- Soluble in ethyl acetate, DMSO (25 mg/ml); dimethyl formamide (25 mg/ml) and slightly soluble in chloroform and methanol
- Insoluble in water
Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5 nM), CDK2/cyclin A (IC50=7 nM), CDK4/cyclin D (IC50=3-10 µM), CDK5/p25 (IC50=4 nM), GSK-3β (IC50=15 nM), Pim-1 kinase (IC50=10 nM).Binds do the ATP binding domain. Did not inhibit PKC-ζ. At 1 µM induced apoptosis in CHO cells. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine.
Formel:
C₂₈H₂₆N₄O₃ MW: 466,541 g/mol Lager Temperatur: Kühlschrank |
MDL Number:
MFCD18252446 CAS-Nummer: 62996-74-1 |
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