Staurosporine ≥98% (durch HPLC)

Lieferant: ENZO LIFE SCIENCES

ALX380014C100 ALX380014C250 ALX380014M001 ALX380014M005
ENZOALX380014C100EA 85 CHF
ENZOALX380014C100 ENZOALX380014C250 ENZOALX380014M001 ENZOALX380014M005
Staurosporine ≥98% (durch HPLC)
Staurosporine

Apoptosis inducer.


  • Protein kinase inhibitor
  • Isolated from Streptomyces staurosporeus
  • Off-white to green powder
  • Soluble in ethyl acetate, DMSO (25 mg/ml); dimethyl formamide (25 mg/ml) and slightly soluble in chloroform and methanol
  • Insoluble in water


Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5 nM), CDK2/cyclin A (IC50=7 nM), CDK4/cyclin D (IC50=3-10 µM), CDK5/p25 (IC50=4 nM), GSK-3β (IC50=15 nM), Pim-1 kinase (IC50=10 nM).Binds do the ATP binding domain. Did not inhibit PKC-ζ. At 1 µM induced apoptosis in CHO cells. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine.

Formel: C₂₈H₂₆N₄O₃
Lager Temperatur: Kühlschrank
MDL Number: MFCD18252446
CAS-Nummer: 62996-74-1

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