Nodularin

Lieferant: ENZO LIFE SCIENCES

ALX350061C100 ALX350061C250 ALX350061M001
ENZOALX350061C100EA 239 CHF
ENZOALX350061C100 ENZOALX350061C250 ENZOALX350061M001
Nodularin
Nodularin

Inhibitor of PP1 and PP2A


Inhibitor of protein phosphatase 1 (PP1) (IC50=1.8nM), protein phosphatase 2A (PP2A) (IC50=0.026nM) and to a lesser extent protein phosphatase 2B (PP2B) (IC50=8.7µm). Similar to microcystin-LR (Prod. No. ALX-350-012) but with increased water solubility. Genotoxic. Hepatoxic. Induces oxidative DNA damage by oxidation of purines. Induces apoptosis in HepG2 cells.


Isolated from Nodularia spumigena.

Formel: C₄₁H₆₀N₈O₁₀
MW: 824.977 g/mol
CAS-Nummer: 118399-22-7

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