[1,2,4]Oxadiazolo[4,3-a]chinoxalin-1-on ≥98% (durch TLC)
Lieferant: ENZO LIFE SCIENCES
Synonyms:
ODQ
ALX270034M010
ALX270034M050
ENZOALX270034M010EA
126
CHF
ENZOALX270034M010
ENZOALX270034M050
[1,2,4]Oxadiazolo[4,3-a]chinoxalin-1-on ≥98% (durch TLC)
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Guanylyl cyclase inhibitor
ODQ is a potent and selective, direct-acting inhibitor of guanylate cyclase (IC50=20 nM). In cerebellar slices ODQ reversibly inhibited cGMP generation in response to endogenous NO or exogenously added NO-donors. ODQ does not inhibit NO-mediated macrophage toxicity (a phenomenon unrelated to cGMP) and does not inhibit particulate guanylyl cyclase or adenylyl cyclase. ODQ is an unique and selective tool to elucidate the physiological importance of the NO-cGMP pathway.
Formel:
C₉H₅N₃O₂ MW: 187.16 g/mol |
MDL Number:
MFCD00792620 CAS-Nummer: 41443-28-1 |
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