[1,2,4]Oxadiazolo[4,3-a]chinoxalin-1-on ≥98% (durch TLC)

Lieferant: ENZO LIFE SCIENCES

Synonyms: ODQ

ALX270034M010 ALX270034M050
ENZOALX270034M010EA 126 CHF
ENZOALX270034M010 ENZOALX270034M050
[1,2,4]Oxadiazolo[4,3-a]chinoxalin-1-on ≥98% (durch TLC)
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

Guanylyl cyclase inhibitor


ODQ is a potent and selective, direct-acting inhibitor of guanylate cyclase (IC50=20 nM). In cerebellar slices ODQ reversibly inhibited cGMP generation in response to endogenous NO or exogenously added NO-donors. ODQ does not inhibit NO-mediated macrophage toxicity (a phenomenon unrelated to cGMP) and does not inhibit particulate guanylyl cyclase or adenylyl cyclase. ODQ is an unique and selective tool to elucidate the physiological importance of the NO-cGMP pathway.

Formel: C₉H₅N₃O₂
MW: 187.16 g/mol
MDL Number: MFCD00792620
CAS-Nummer: 41443-28-1

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