Midostaurin ≥98% (durch TLC)

Lieferant: ENZO LIFE SCIENCES

BMLEI3700001 BMLEI3700005
ENZOBMLEI3700001EA 183 CHF
ENZOBMLEI3700001 ENZOBMLEI3700005
Midostaurin ≥98% (durch TLC)
Midostaurin

Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.


  • Flt inhibitor


White to off-white powder.


Soluble in DMSO (15mg/ml), MDC (10mg/ml), methanol (5mg/ml) or 100% ethanol (2.5mg/ml).

Formel: C₃₅H₃₀N₄O₄
Lager Temperatur: Gefrierschrank
MDL Number: MFCD12828879
CAS-Nummer: 120685-11-2
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