Troglitazone ≥98% (durch TLC)
Lieferant: ENZO LIFE SCIENCES
Synonyms:
5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)thiazolidine-2,4-dione
PPAR ligand
Antidiabetic thiazolidinedione. Potent and selective PPARγ ligand. Binds to the PPARγ ligand-binding domain and recruits ligand-specific transcriptional coactivators at 1µM. In skeletal muscle and adipocyte cell cultures, the EC50 of troglitazone is about 10µM. Displaces [125I]SB-236636 with an IC50=7.9 µM. Stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. Induces apoptosis in human vascular smooth muscle cells and inhibits the growth of a variety of human cancer cells including lung, bladder and myeloid leukemia cells.
Synthetic.
Formel:
C₂₄H₂₇NO₅S MW: 441,5 g/mol |
MDL Number:
MFCD00878416 CAS-Nummer: 97322-87-7 |
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