Calcitriol 99 HPLC_ASSAY_METHOD
Lieferant: ENZO LIFE SCIENCES
Synonyms:
1,25-Dihydroxycholecalciferol, (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-Hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol, 1alpha,25-Dihydroxyvitamin D3
Ultra-high purity
1α,25-Dihydroxyvitamin D3 is the active hormonal form of vitamin D. It inhibits proliferation and induces differentiation of a variety of cells including osteoclasts, HL-60 cells. It is a central regulator of bone and calcium homeostasis. A polymorphism in the vitamin D receptor gene has been linked to a genetic predisposition to osteoporosis. It inhibits proliferation and induces differentiation of a variety of cells including osteoclasts, keratinocytes, HL-60 cells vascular smooth muscle cells and bone marrow macrophage precursors. It can activate signal transduction pathways that include hydrolysis of phosphatidylcholine and formation of diacylglycerol in chick myoblasts, and activation of Raf kinase in rat hepatic primary cells and 3T3 fibroblasts. It regulates c-myc protooncogene transcription, interleukin-8 expression, induction of cyclooxygenase, and directly activates protein kinase C at physiological concentrations (EC50=16 nM). Up-regulates RANKL level and down-regulates OPG level.
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Formel:
C₂₇H₄₄O₃ MW: 416.646 g/mol |
MDL Number:
MFCD00867079 CAS-Nummer: 32222-06-3 |
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