Anti-HSP70 Mouse Monoclonal Antibody (Biotin)

Lieferant: Enzo Life Sciences
ENZOADISPA810BFEA 769 CHF
ENZOADISPA810BF ENZOADISPA810BD ALEXADI-SPA-810B-F ALEXADI-SPA-810B-D
Anti-HSP70 Mouse Monoclonal Antibody (Biotin)
Antikörper
The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

  • For Western Blot

Recognizes human, mouse, rat, avian, hamster, monkey, rabbit, guinea pig, bovine, chicken, sheep, chicken, fish, pig and beluga HSP70 (HSP72). Detects a band of ~70kDa by Western blot.

Type: Primary
Antigen: HSP70
Clonality: Monoclonal
Clone:
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human
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