Anti-DUSP4 Mouse Monoclonal Antibody [clone: AFPK7]

Lieferant: AbFrontier
LF-MA0302
ABFRLF-MA0302EA 311 CHF
ABFRLF-MA0302
Anti-DUSP4 Mouse Monoclonal Antibody [clone: AFPK7]
Antikörper
There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells.
MKP2(DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs(ERK, JNK, p38). It contains one Rhodanese domain and one tyrosine-protein phosphatase domain.
MKP2 is expressed in a variety of tissues, and is localized in the nucleus.
Transcription factor E2F-1 acts as a transcriptional regulator of MKP2. E2F-1/MKP2 pathway mediates apoptosis under oxidative stress and that MKP2 suppresses tumor formation.
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