Sie suchten nach: KING DISPOSABLES

Beschreibung: The 2A3 immunoglobulin is useful as an isotype-matched control. The 2A3 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2a antibodies.

Artikel-Nr: 55-4321-U100

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 55-4321-U100

Lieferant: Tonbo Biosciences

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Beschreibung: Purified Rat IgG2a Isotype Control (2A3)

Artikel-Nr: 70-4321-U100

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 70-4321-U100

Lieferant: Tonbo Biosciences

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Beschreibung: The EBVCS-5 antibody is specific for human CD23, also known as the low affinity IgE receptor (FceRII), a 45 kDa type II transmembrane protein and member of the immunoglobulin superfamily. It is expressed on most B cells and is upregulated upon activation. It is also present on mantle zone B cells, eosinophils, monocytes and a subset of T cells and platelets. CD23 plays a role in B cell development and differentiation, and also functions to regulate IgE production. Soluble secreted forms of CD23 have been reported to bind IgE, stimulate release of pro-inflammatory cytokines from monocytes, and play a role in B cell differentiation.

Artikel-Nr: 20-0237-T500

UOM: 1 * 500 Tests

Hersteller Artikel Nummer : 20-0237-T500

Lieferant: Tonbo Biosciences

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Beschreibung: The HIT2 antibody is specific for human CD38, a 45 kD type II transmembrane glycoprotein expressed on thymocytes, activated T and B cells, and monocytes as well as other non-hematopoietic cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.

Artikel-Nr: 65-0389-T100

UOM: 1 * 100 Tests

Hersteller Artikel Nummer : 65-0389-T100

Lieferant: Tonbo Biosciences

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Beschreibung: The BM8.1 antibody is specific for mouse F4/80 antigen, a 125 kDa transmembrane protein widely expressed by members of the mononuclear phagocyte system and considered to be a key marker for mature macrophage cells. F4/80 is differentially expressed during myeloid cell development, and may be regulated by certain cytokines within the tissue microenvironment. Other cell types shown to express this antigen include Langerhans cells, Kupffer cells and dendritic cell subsets. BM8.1 is widely used together with antibodies to CD115 (c-fms), CD11b and CD11c to identify myeloid / macrophage cells by flow cytometry.

Artikel-Nr: 60-4801-U100

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 60-4801-U100

Lieferant: Tonbo Biosciences

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Beschreibung: The M1/69 antibody reacts with mouse CD24, a cell surface molecule also known as Heat Stable Antigen (HSA). CD24 is a GPI-linked glycoprotein involved in cell adhesion and is a ligand for CD62P (P-selectin). It is expressed on erthrocytes, thymocytes, peripheral lymphocytes and myeloid lineage cells. The expression of CD24 is used to delineate stages of of lymphocyte development in the bone marrow.

Artikel-Nr: 50-0242-U100

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 50-0242-U100

Lieferant: Tonbo Biosciences

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Beschreibung: The MY31 antibody reacts with human CD56, also known as the neural cell adhesion molecule (NCAM), a glycoprotein which is a member of the immunoglobulin superfamily. The 140 kDa isoform of CD56 is expressed on human NK cells and NK-T cells, with increased expression levels on activated NK lymphocytes. The CD56 antigen is also expressed by neurons and is reported to play a role in nervous system development and neural cell-to-cell adhesion.

Artikel-Nr: 20-0564-T100

UOM: 1 * 100 Tests

Hersteller Artikel Nummer : 20-0564-T100

Lieferant: Tonbo Biosciences

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Beschreibung: The MPC-11 immunoglobulin is useful as an isotype-matched control. The MPC-11 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2b antibodies.

Artikel-Nr: 75-4732-U100

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 75-4732-U100

Lieferant: Tonbo Biosciences

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Beschreibung: The 30-H12 antibody reacts with mouse CD90.2 (Thy1.2). CD90.2 is a strain-specific allelic form of the GPI-linked membrane associated protein CD90 and is involved in adhesion and signal transduction. CD90.2 is expressed on thymocytes, mature T cells and neurons in mouse strains that express the CD90.2 allele (BALB/c, CBA, C3H, C57BL/6, SJL and others). 30-H12 does not react with the CD90.1 allele expressed in mouse strains such as PL and AKR.

Artikel-Nr: 75-0903-U100

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 75-0903-U100

Lieferant: Tonbo Biosciences

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Beschreibung: The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.

Artikel-Nr: 40-5874-U100

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 40-5874-U100

Lieferant: Tonbo Biosciences

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Beschreibung: The UCHL1 antibody reacts with the human CD45 isoform known as CD45RO, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA and CD45RB.

Artikel-Nr: 50-0457-T100

UOM: 1 * 100 Tests

Hersteller Artikel Nummer : 50-0457-T100

Lieferant: Tonbo Biosciences

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Beschreibung: The BNI3 antibody is specific for human CD152, commonly known as CTLA-4, a 33 to 37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

Artikel-Nr: 50-1529-T025

UOM: 1 * 25 Tests

Hersteller Artikel Nummer : 50-1529-T025

Lieferant: Tonbo Biosciences

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Beschreibung: The A7R34 antibody is specific for mouse CD127, a 60 to 90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.

Artikel-Nr: 35-1271-U500

UOM: 1 * 500 µG

Hersteller Artikel Nummer : 35-1271-U500

Lieferant: Tonbo Biosciences

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Beschreibung: The HI100 antibody reacts with the human CD45 isoform known as CD45RA, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RB and CD45RO.

Artikel-Nr: 20-0458-T100

UOM: 1 * 100 Tests

Hersteller Artikel Nummer : 20-0458-T100

Lieferant: Tonbo Biosciences

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Beschreibung: The UCHL1 antibody reacts with the human CD45 isoform known as CD45RO, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA and CD45RB.

Artikel-Nr: 65-0457-T100

UOM: 1 * 100 Tests

Hersteller Artikel Nummer : 65-0457-T100

Lieferant: Tonbo Biosciences

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Beschreibung: The HRPN immunoglobulin is useful as an isotype-matched control. The HRPN immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG1 antibodies.

Artikel-Nr: 60-4301-U100

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 60-4301-U100

Lieferant: Tonbo Biosciences

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