Sie suchten nach: ProSci Inc.

Artikel-Nr: (PRSI91-918)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 91-918

Beschreibung: Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI27-221)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 27-221

Beschreibung: TRAF4 is a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. It has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD (P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK.This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD (P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI5633P)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 5633P

Beschreibung: DCLK1 pepide is used for blocking the activity of DCLK1 antibody.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI25-753)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 25-753

Beschreibung: An antibody that reacts with ovarian cancers and mesotheliomas was used to isolate a cell surface antigen named mesothelin. Although the function of mesothelin is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin.An antibody that reacts with ovarian cancers and mesotheliomas was used to isolate a cell surface antigen named mesothelin. Although the function of mesothelin is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI92-429)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 92-429

Beschreibung: Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralisation of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI96-425)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 96-425

Beschreibung: Interleukin 13 receptor, alpha 1 is also known as IL13RA1, NR4 and CD213A1 (cluster of differentiation 213A1), The IL13 Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. Human and mouseIL13Rα1 share 76% aa sequence identity. IL13RA1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

UOM: 1 * 100 µG

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Artikel-Nr: (PRSI96-747)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 96-747

Beschreibung: Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

UOM: 1 * 100 µG

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Artikel-Nr: (PRSI96-504)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 96-504

Beschreibung: Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) is also known as CD antigen CD306. LAIR2 contains one Ig-like C2-type (immunoglobulin-like) domain. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 / CD306 is thought to be secreted and may help modulate mucosal tolerance.

UOM: 1 * 100 µG

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Artikel-Nr: (PRSI96-695)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 96-695

Beschreibung: Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

UOM: 1 * 100 µG

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Artikel-Nr: (PRSI6299P)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 6299P

Beschreibung: SIK1 peptide is used for blocking the activity of SIK1 antibody.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI6449P)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 6449P

Beschreibung: Paralemmin3 peptide is used for blocking the activity of Paralemmin3 antibody.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI6487P)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 6487P

Beschreibung: EI24 peptide is used for blocking the activity of EI24 antibody.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI6551P)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 6551P

Beschreibung: SPATA3 peptide is used for blocking the activity of SPATA3 antibody.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI2241)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 2241

Beschreibung: Acinus Antibody: Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS'.

UOM: 1 * 100 µG

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Artikel-Nr: (PRSI2255P)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 2255P

Beschreibung: SnoN peptide is used for blocking activity of SnoN antibody.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI6407P)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 6407P

Beschreibung: SPRYD4 peptide is used for blocking the activity of SPRYD4 antibody.

UOM: 1 * 50 µG

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