Sie suchten nach: Gewichte

Beschreibung: Neuregulin 1-beta (NRG1-β) is one of many alternatively-spliced isoforms of the NRG1 gene and contains a soluble EGF-like domain. The EGF-like domain of NRG1-β signals through the ErbB2, ErbB3, and ErbB4 receptor tyrosine kinases. NRG1-β is an important growth factor involved in neuroinflammation, nerve regeneration, and cardiovascular processes.

Artikel-Nr: SHBT100-46-50UG

UOM: 1 * 50 µG

Hersteller Artikel Nummer : 100-46-50UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Fibroblast growth factor 21 (FGF-21) is an endocrine hormone that regulates energy homeostasis and exerts cardioprotective functions during heart injury. FGF-21 is expressed in the liver, pancreas, heart, and adipose tissues. FGF-21 signaling is activated through the FGFR1c receptor and β-Klotho co-receptor. FGF-21 is an important regulator of glucose uptake and reduces cell apoptosis under stress conditions.

Artikel-Nr: SHBT100-148AF100UG

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 100-148AF100UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the tumor necrosis factor (TNF) family of proteins. RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. T cell expression of RANK Ligand promotes dendritic cell maturation.

Artikel-Nr: SHBT100-18AF-500UG

UOM: 1 * 500 µG

Hersteller Artikel Nummer : 100-18AF-500UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Stromal cell-derived factor-1 alpha (SDF-1 α), also called CXCL12a, is one of two SDF-1 splice variants made by a wide variety of cells upon stimulation by inflammatory cytokines such as TNF, IL-1, and LPS. SDF-1α signals through the G protein-coupled receptor CXCR4 to recruit activated leukocytes. Human and mouse SDF-1 α share 99% sequence identity.

Artikel-Nr: SHBT100-19AF-100UG

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 100-19AF-100UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Nerve growth factor beta (β-NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. β-NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. β-NGF is also involved in the growth, differentiation, and survival of B lymphocytes. Human, mouse, and rat β-NGF proteins are cross-reactive.

Artikel-Nr: SHBT200-11AF-5UG

UOM: 1 * 5 µG

Hersteller Artikel Nummer : 200-11AF-5UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Eotaxin, also known as Eotaxin-1 and CCL11, is a chemokine that recruits eosinophils to sites of allergic inflammation. Eotaxin signals through the G protein-coupled chemokine receptors CCR2, CCR3, and CCR5.

Artikel-Nr: SHBT100-178-5UG

UOM: 1 * 5 µG

Hersteller Artikel Nummer : 100-178-5UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.

Artikel-Nr: SHBT100-195-20UG

UOM: 1 * 20 µG

Hersteller Artikel Nummer : 100-195-20UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Macrophage inflammatory protein-1 alpha (MIP-1 α), also known as CCL3, is a cytokine produced by macrophages. MIP-1 α binds the chemokine receptors CCR1, CCR4 and CCR5 to induce inflammatory responses, including the recruitment of granulocytes and neutrophil superoxide production. The MIP-1 α and MIP-1 β heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1).

Artikel-Nr: SHBT300-14-200UG

UOM: 1 * 200 µG

Hersteller Artikel Nummer : 300-14-200UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Interleukin 33 (IL-33) is a member of the IL-1 cytokine family and is constitutively expressed in smooth muscle and airway epithelial cells. IL-33 signals through the interleukin 1 receptor-like 1 (IL-1R1) and interleukin-1 receptor accessory protein (IL1RAP) receptors to ativate NF-κB and MAPK signaling pathways. IL-33 functions to induce type 2 cytokine production in polarized Type 2 helper T (Th2) cells.

Artikel-Nr: SHBT100-145-10UG

UOM: 1 * 10 µG

Hersteller Artikel Nummer : 100-145-10UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: B cell-activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a type II member of the tumor necrosis factor (TNF) superfamily. BAFF is expressed as a transmembrane protein on T cells, macrophages, and dendritic cells. The transmembrane domain of BAFF can also be cleaved to produce a soluble protein fragment.

Artikel-Nr: SHBT100-24-5UG

UOM: 1 * 5 µG

Hersteller Artikel Nummer : 100-24-5UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Macrophage migration inhibitory factor (MIF) is a pro-inflammatory lymphokine that functions during cell-mediated immmunity. MIF promotes fibroblast migration by inducing interleukin 1 (IL-1), interleukin 8 (IL-8), and matrix metalloproteinase (MMP) expression. In interferon-gamma-activated macrophages, MIF stimulates nitric oxide (NO) production and tumor necrosis factor alpha (TNF-α) secretion.

Artikel-Nr: SHBT200-78-500UG

UOM: 1 * 500 µG

Hersteller Artikel Nummer : 200-78-500UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.

Artikel-Nr: SHBT100-44AF-100UG

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 100-44AF-100UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Macrophage colony stimulating factor (M-CSF) is a hematopoietic growth factor that is widely produced by a variety of cells. M-CSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types.

Artikel-Nr: SHBT100-03AF-100UG

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 100-03AF-100UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Cytokines for expansion and cell culture of human hematopoietic stem cells to progenitor cells. Hematopoietic stem cells are self renewing pluripotent cells often characterized by the expression of CD34. Studies have shown that decreased expression of CD34 tends to correlate with the decreased self renewal properties and pluripotent potential. Culturing CD34+ cells in a cytokine mixture of SCF, FLT-3 Ligand, IL-6 and IL-3 for short time periods allows rapid expansion of immature and more mature hematopoietic progenitor cells in cord blood or bone marrow preparations. If the goal is to only expand the most immature progenitor and stem cells, it is recommended that a combination of TPO, SCF and FLT-3 Ligand are used (Catalog: PB-500-03). Either cytokine combination can also be supplemented with other cytokines to promote specific lineages.

Artikel-Nr: SHBTPB-500-07

UOM: 1 * 1 KIT

Hersteller Artikel Nummer : PB-500-07

Lieferant: Shenandoah Biotechnology

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Beschreibung: Interleukin-19 (IL-19) is a member of the interleukin 10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin 20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-a) expression in monocytes, and promotes T helper 2 (Th2) cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide (LPS) stimulation.

Artikel-Nr: SHBT100-88-10UG

UOM: 1 * 10 µG

Hersteller Artikel Nummer : 100-88-10UG

Lieferant: Shenandoah Biotechnology

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Beschreibung: Fibroblast growth factor 9 (FGF-9) is a mitogen and survival factor for nerve and mesenchymal cells. FGF-9 functions as an autocrine and paracrine factor to support the growth and survival of motor neurons and prostate tissue. FGF-9 expression in the gonad is also necessary for sex determination.

Artikel-Nr: SHBT100-215AF-100U

UOM: 1 * 100 µG

Hersteller Artikel Nummer : 100-215AF-100U

Lieferant: Shenandoah Biotechnology

New Product Sale