Sie suchten nach: 1-(Dimethylamino)-2-propanol

Artikel-Nr: (BOSSBS-7706R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7706R-CY3

Beschreibung: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-15499R-CY5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15499R-CY5

Beschreibung: CYP2S1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localises to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolise certain carcinogens; however, the specific function of the human protein has not been determined.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-15499R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15499R-A750

Beschreibung: CYP2S1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localises to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolise certain carcinogens; however, the specific function of the human protein has not been determined.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-4000R-A350)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-4000R-A350

Beschreibung: Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-15499R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15499R-HRP

Beschreibung: CYP2S1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localises to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolise certain carcinogens; however, the specific function of the human protein has not been determined.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-7764R-CY7)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7764R-CY7

Beschreibung: NUSAP1 is a microtubule-associated protein with the capacity to bundle and stabilize microtubules. It may associate with chromosomes and promote the organization of mitotic spindle microtubules around them. There are five different isoforms.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-15453R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15453R-A555

Beschreibung: HEMK2 is a 214 amino acid protein that belongs to the methyltransferase superfamily and exists as multiple alternatively spliced isoforms. The gene encoding HEMK2 maps to human chromosome 21, which houses approximately 300 genes and comprises nearly 1,5% of the human genome. Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-7708R-A488)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7708R-A488

Beschreibung: Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53.Tissue specificity:Expressed in all tissues examined. Isoforms are differentially expressed. Isoform 3 and isoform 5 were highly expressed, isoform 4 moderately expressed, isoform 2 lower expression, the lowest expression level was seem with isoform 1.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-11322R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11322R-HRP

Beschreibung: The gene encoding human Membralin, C19orf6, localizes to chromosome 19p13.3. It contains 11 exons, which encode at least two splice variants in human cancer. Membralin is a multi-pass membrane protein and exists either as a long or short form. The long form of Membralin comprises all 11 exons, while the short form contains all exons except exon 10. Expression of different Membralin isoforms depends on tissue type. The long form is expressed in ovarian and colorectal carcinomas, whereas the short form is expressed in breast or pancreatic carcinomas. Because Membralin expression in ovarian carcinomas is highest in serous carcinomas as compared to surface epithelium carcinomas, expression of Membralin may be useful as a novel tumor-associated marker in ovarian serous carcinomas.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-11324R-A350)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11324R-A350

Beschreibung: Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-7763R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7763R-A555

Beschreibung: Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-3943R-FITC)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3943R-FITC

Beschreibung: G proteins are composed of 3 units, alpha, beta and gamma and are involved in the modulation and transduction of various transmembrane signalling systems. There are families of related genes for each subunit. GNB3 encodes a beta subunit. Beta subunits are required for GTPase activity, for replacement of GDP by GTP, regulate alpha subunits and for G protein-effector interactions. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity and is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-3943R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3943R-CY3

Beschreibung: G proteins are composed of 3 units, alpha, beta and gamma and are involved in the modulation and transduction of various transmembrane signalling systems. There are families of related genes for each subunit. GNB3 encodes a beta subunit. Beta subunits are required for GTPase activity, for replacement of GDP by GTP, regulate alpha subunits and for G protein-effector interactions. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity and is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-11323R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11323R-A750

Beschreibung: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-7763R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7763R-HRP

Beschreibung: Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-11323R-CY5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11323R-CY5

Beschreibung: Neuroglycan C is a brain-specific chondroitin sulfate proteoglycan (CSPG) implicated in the proliferation of neural stem and progenitor cells. Neuro-glycan C is a single-pass membrane protein that can manifest as a part-time proteoglycan depending on the tissue expressing it. In its proteoglycan form, Neuroglycan C exhibits chondroitin sulfate glycans and functions as a receptor for midkine, a growth factor that binds heparin, to affect cytoskeletal changes. By means of ectodomain shedding, the ectodomain of Neuroglycan C is able to enhance neurite outgrowth from neurons. Neurite growth stimulation is affected by both an EGF-like and an acidic amino acid domain found on the shed ectodomain. Both domains instigate neurite growth, however, these domains exhibit differing functionality as to number of neurites produced and neuron types stimulated.

UOM: 1 * 100 µl

Sale