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Anti-Smad1 + Smad5 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-1619R-A555)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1619R-A555
Beschreibung: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4237R-A750

Anti-BMPR2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Artikel-Nr: (BOSSBS-4237R-A750)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-4237R-A750
Beschreibung: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
UOM: 1 * 100 µl

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Product Image-1.73635.0001

Portable colorimeter for disinfection control, Spectroquant® Move Cl₂/O₃/ClO₂/CyA/pH

Artikel-Nr: (1.73635.0001)
Lieferant: Merck
Hersteller Artikel Nummer : 1.73635.0001
Beschreibung: The mobile and robust Spectroquant® Move Cl₂/O₃/ClO₂/CyA/pH colorimeter covers five key important parameters for disinfection control (mainly Food and Beverage segment).
UOM: 1 * 1 ST
Image Unavailable-BOSSBS-4237R-CY7

Anti-BMPR2 Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-4237R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-4237R-CY7
Beschreibung: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3582R-A350

Anti-T1 gamma Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Artikel-Nr: (BOSSBS-3582R-A350)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-3582R-A350
Beschreibung: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3582R-A680

Anti-T1 gamma Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Artikel-Nr: (BOSSBS-3582R-A680)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-3582R-A680
Beschreibung: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1778R-CY7

Anti-GATA4 Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-1778R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1778R-CY7
Beschreibung: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6978R

Anti-ZNF521 Rabbit Polyclonal Antibody

Artikel-Nr: (BOSSBS-6978R)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6978R
Beschreibung: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1778R-CY3

Anti-GATA4 Rabbit Polyclonal Antibody (Cy3®)

Artikel-Nr: (BOSSBS-1778R-CY3)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1778R-CY3
Beschreibung: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3670R

Anti-BMP8B Rabbit Polyclonal Antibody

Artikel-Nr: (BOSSBS-3670R)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-3670R
Beschreibung: The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4237R-HRP

Anti-BMPR2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Artikel-Nr: (BOSSBS-4237R-HRP)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-4237R-HRP
Beschreibung: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4237R-A647

Anti-BMPR2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Artikel-Nr: (BOSSBS-4237R-A647)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-4237R-A647
Beschreibung: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3818R-CY3

Anti-GDF15 Rabbit Polyclonal Antibody (Cy3®)

Artikel-Nr: (BOSSBS-3818R-CY3)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-3818R-CY3
Beschreibung: Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues.GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1619R-A647

Anti-Smad1 + Smad5 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Artikel-Nr: (BOSSBS-1619R-A647)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1619R-A647
Beschreibung: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1619R-A750

Anti-Smad1 + Smad5 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Artikel-Nr: (BOSSBS-1619R-A750)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1619R-A750
Beschreibung: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-10381R-A350

Anti-SMAD1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Artikel-Nr: (BOSSBS-10381R-A350)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-10381R-A350
Beschreibung: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].
UOM: 1 * 100 µl
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