Sie suchten nach: trans-4-Fluoro-L-proline

Artikel-Nr: (ENZOALX210351R400)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX210351R400

Beschreibung: Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP).
Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signalling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.

UOM: 1 * 400 µl

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Lieferant: Apollo Scientific

Beschreibung: N-t-BOC-trans-4-Fluoro-L-prolinonitrile

Artikel-Nr: (APOSPC540076-1G)

Lieferant: Apollo Scientific

Hersteller Artikel Nummer : PC540076-1G

Beschreibung: trans-4-Fluoro-3-hydroxypyrrolidine hydrochloride 98

UOM: 1 * 1 g

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Artikel-Nr: (APOSPC402117-1G)

Lieferant: Apollo Scientific

Hersteller Artikel Nummer : PC402117-1G

Beschreibung: trans-3-Fluoro-3-methylcyclobutane-1-carboxylic acid 97%

UOM: 1 * 1 g

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Artikel-Nr: (PRSI91-195)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 91-195

Beschreibung: Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but prolines unusual structure stabilizes the cis form so that both isomers are populated under biologically relevant conditions. Proteins with prolyl isomerase activity include cyclophilin, FKBPs, and parvulin, although larger proteins can also contain prolyl isomerase domains.

UOM: 1 * 50 µG

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Lieferant: Apollo Scientific

Beschreibung: Fmoc-trans-4-fluoro-Pro-Oh

Lieferant: Thermo Fisher Scientific

Beschreibung: 4-Fluoro-trans-β-styrylboronic acid pinacol ester 97%

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Artikel-Nr: (PRSI29-363)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 29-363

Beschreibung: PPIE is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities and also exhibit RNA-binding activityThe protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities and also exhibit RNA-binding activity. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.

UOM: 1 * 100 µG

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Artikel-Nr: (PRSI30-165)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 30-165

Beschreibung: PPIF is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.

UOM: 1 * 100 µG

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Artikel-Nr: (PRSI26-205)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 26-205

Beschreibung: FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin.FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).

UOM: 1 * 50 µG

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Lieferant: Apollo Scientific

Beschreibung: trans-tert-Butyl 3-fluoro-4-hydroxypyrrolidine-1-carboxylate

Artikel-Nr: (APOSPC430262-1G)

Lieferant: Apollo Scientific

Hersteller Artikel Nummer : PC430262-1G

Beschreibung: trans-3-Fluoro-tetrahydro-2H-pyran-4-yl methanesulphonate racemate

UOM: 1 * 1 g

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Lieferant: Apollo Scientific

Beschreibung: trans-4-Fluor-β-nitrostyrol 98%

Artikel-Nr: (PRSI92-055)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 92-055

Beschreibung: Peptidyl-Prolyl Cis-Trans Isomerase D (PPID) belongs to the cyclophilin-type PPIase family and PPIase D subfamily. PPID is widely expressed and it contains one PPIase cyclophilin-type domain and three TPR repeats. PPID catalyses the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. PPID can bind to the immunosuppressant cyclosporine A and is known that its overexpression suppresses the apoptosis in cancer cells.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI91-233)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 91-233

Beschreibung: Peptidyl-Prolyl Cis-Trans Isomerase H (PPIH) belongs to the Cyclophilin-type PPIase family that accelerate the folding of proteins. PPIases can catalyze the cis-trans isomerisaion of Proline Imidic peptide bonds in oligopeptides. PPIH participates in pre-mRNA splicing. It is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. In addition, PPIH has PPIase activity and may play a role as a chaperone mediating the interactions between different proteins inside the spliceosome.

UOM: 1 * 50 µG

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Artikel-Nr: (PRSI91-271)

Lieferant: ProSci Inc.

Hersteller Artikel Nummer : 91-271

Beschreibung: Peptidyl-Prolyl Cis-Trans Isomerase-Like 1 (PPIase) belongs to the cyclophilin-type PPIase family. PPIases can accelerate the folding of proteins and catalyze the cis-trans isomerisaion of proline imidic peptide bonds in oligopeptides. PPIase is a ubiquitous protein and has highly expression in heart ,skeletal and muscle. PPIase contains a PPIase cyclophilin-type domain and four Cyclosporin A binding regions. PPIase might play an important role in proliferation of cancer cells through modulation of phosphorylation of stathmin. It is suggested that PPIase can act as as a novel molecular target for colon-cancer therapy.

UOM: 1 * 50 µG

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