Sie suchten nach: lamins

Artikel-Nr: (BRDY321992)

Lieferant: Brady

Hersteller Artikel Nummer : 321992

Beschreibung: Prima 8 laminating film with snowflake design.

UOM: 1 * 1 ST

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Artikel-Nr: (BSENR-1697-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : R-1697-100

Beschreibung: The Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm (1). The lamins function as skeletal components tightly associated with the inner nuclear membrane. Originally the proteins of the nuclear cytoskeleton were named Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that lamins A and C were coded for by a single gene (2), while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74kDa while Lamin C is 65kDa. The Lamin A protein includes 98 amino acids missing from Lamin C, while Lamin C has a C-terminal 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other, as is the case with this monoclonal. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kinase 1 (CDK1), the key component of "maturation promoting factor", the central regulator of cell division. Activity of this kinase increases during cell division and is responsible for the breakdown of the nuclear lamina. Mutations in the LMNA gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lamina binding proteins. A truncated version of lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging (3).

UOM: 1 * 100 µl

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Artikel-Nr: (USBI144828)

Lieferant: US Biological

Hersteller Artikel Nummer : 144828

Beschreibung: Anti-Lamin-B1 Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

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Lieferant: VWR Collection

Beschreibung: Zum Aufteilen des Siebguts in repräsentative Analysensiebproben.

Artikel-Nr: (BWRLBS7013)

Lieferant: Bioworld Technology

Hersteller Artikel Nummer : BS7013

Beschreibung: Synthetic peptide, corresponding to amino acids 180-230 of Human Lamin A.

UOM: 1 * 100 µG

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Lieferant: Brady

Beschreibung: Prima 8 Klare Laminat-Patchfolie für Prima 8-Laminiergerät.

New Product

Artikel-Nr: (USBIL1220-12A)

Lieferant: US Biological

Hersteller Artikel Nummer : L1220-12A

Beschreibung: Anti-Lamin A, C Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

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Artikel-Nr: (BWRLBS3774)

Lieferant: Bioworld Technology

Hersteller Artikel Nummer : BS3774

Beschreibung: Synthetic peptide, corresponding to the N-terminus of Human Lamin A.

UOM: 1 * 100 µG

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Artikel-Nr: (BOSSBS-11132R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11132R-A750

Beschreibung: A unique family of Cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed CED-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology as components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family.

UOM: 1 * 100 µl

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Artikel-Nr: (BSENC-1698-100)

Lieferant: Biosensis

Hersteller Artikel Nummer : C-1698-100

Beschreibung: The Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm (1). The lamins function as skeletal components tightly associated with the inner nuclear membrane. Originally the proteins of the nuclear cytoskeleton were named Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that lamins A and C were coded for by a single gene (2), while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74kDa while Lamin C is 65kDa. The Lamin A protein includes 98 amino acids missing from Lamin C, while Lamin C has a C-terminal 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other, as is the case with this monoclonal. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kinase 1 (CDK1), the key component of "maturation promoting factor", the central regulator of cell division. Activity of this kinase increases during cell division and is responsible for the breakdown of the nuclear lamina. Mutations in the LMNA gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lamina binding proteins. A truncated version of lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging (3).

UOM: 1 * 100 µl

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Lieferant: Novus Biologicals

Beschreibung: Anti-Lamin A + C R482W Mouse Monoclonal Antibody [clone: 5H8-B4]

Artikel-Nr: (USBIL1220-11B)

Lieferant: US Biological

Hersteller Artikel Nummer : L1220-11B

Beschreibung: Anti-Lamin A, C Mouse Monoclonal Antibody [clone: 5F293]

UOM: 1 * 5 mL

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Artikel-Nr: (BOSSBS-3254R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3254R-A555

Beschreibung: Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A type lamins coincides with cell differentiation and as A type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A type lamins.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3254R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3254R-CY3

Beschreibung: Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A type lamins coincides with cell differentiation and as A type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A type lamins.

UOM: 1 * 100 µl

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Artikel-Nr: (USBIL1220-50A)

Lieferant: US Biological

Hersteller Artikel Nummer : L1220-50A

Beschreibung: Anti-Lamin C Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Artikel-Nr: (USBIL1220-08F)

Lieferant: US Biological

Hersteller Artikel Nummer : L1220-08F

Beschreibung: Anti-Lamin A, C Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

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