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Artikel-Nr: (BOSSBS-3485R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-3485R-CY7
Beschreibung: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).
UOM: 1 * 100 µl


Artikel-Nr: (BOSSBS-5662R-A680)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5662R-A680
Beschreibung: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).
UOM: 1 * 100 µl


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Artikel-Nr: (USBI038926-APC)
Lieferant: US Biological
Hersteller Artikel Nummer : 038926-APC
Beschreibung: Anti-NF kappa B Rabbit Polyclonal Antibody (APC (Allophycocyanin))
UOM: 1 * 200 µl


Artikel-Nr: (ROCKKAA064)
Lieferant: Rockland Immunochemicals
Hersteller Artikel Nummer : KAA064
Beschreibung: These assays are non-radioactive methods for detecting specific transcription factor DNA binding activity in nuclear extracts and whole cell lysates. A specific dsDNA sequence containing the NF[kappa]B response element is immobilized on the bottom of the wells in a 96-well plate. The transcription factor is detected by the addition of a specific primary antibody. A colorimetric readout at 450 nm is obtained through a horseradish peroxidase-conjugated secondary antibody.
UOM: 1 * 1 KIT


Artikel-Nr: (AGRIAS101407)
Lieferant: Agrisera
Hersteller Artikel Nummer : AS101407
Beschreibung: Anti-kappa light chain Goat Polyclonal Antibody (TRITC (Tetramethylrhodamine Isothiocyanate))
UOM: 1 * 0,5 mg


Artikel-Nr: (USBII1903-37N)
Lieferant: US Biological
Hersteller Artikel Nummer : I1903-37N
Beschreibung: Anti-IgG kappa Goat Polyclonal Antibody (Biotin)
UOM: 1 * 1 mg


Artikel-Nr: (ROCK012-001-332)
Lieferant: Rockland Immunochemicals
Hersteller Artikel Nummer : 012-001-332
Beschreibung: Rat IgG2a Kappa isotype control can be utilized as a control or standard reagent in Western Blotting, Flow Cytometry, and ELISA experiments where determination of sample isotype is important. Specific conditions should be optimized by user.
UOM: 1 * 500 µG


Artikel-Nr: (ROCK012-001-334)
Lieferant: Rockland Immunochemicals
Hersteller Artikel Nummer : 012-001-334
Beschreibung: Rat IgG2b Kappa isotype control can be utilized as a control or standard reagent in Western Blotting, Flow Cytometry, and ELISA experiments where determination of sample isotype is important. Specific conditions should be optimized by user.
UOM: 1 * 500 µG


Artikel-Nr: (USBI141701-50)
Lieferant: US Biological
Hersteller Artikel Nummer : 141701-50
Beschreibung: Anti-Nuclear Factor Kappa B Rabbit Polyclonal Antibody
UOM: 1 * 50 µG


Artikel-Nr: (USBI128720)
Lieferant: US Biological
Hersteller Artikel Nummer : 128720
Beschreibung: Anti-Kappa Light Chain Mouse Monoclonal Antibody [clone: 1F6]
UOM: 1 * 100 µG


Artikel-Nr: (BOSSBS-1194R-FITC)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1194R-FITC
Beschreibung: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally.
UOM: 1 * 100 µl


Artikel-Nr: (BOSSBS-1194R-HRP)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1194R-HRP
Beschreibung: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally.
UOM: 1 * 100 µl


Artikel-Nr: (USBII1903-54H)
Lieferant: US Biological
Hersteller Artikel Nummer : I1903-54H
Beschreibung: Anti-kappa light chain Goat Polyclonal Antibody (TRITC (Tetramethylrhodamine Isothiocyanate))
UOM: 1 * 500 µG


Artikel-Nr: (USBIK0090-01A)
Lieferant: US Biological
Hersteller Artikel Nummer : K0090-01A
Beschreibung: Anti-Kappa Light Chainkappa light chain, F Rabbit Polyclonal Antibody (Biotin)
UOM: 1 * 500 µG


Artikel-Nr: (USBII1903-36R)
Lieferant: US Biological
Hersteller Artikel Nummer : I1903-36R
Beschreibung: Anti-IgG kappa Goat Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
UOM: 1 * 1 mg


Artikel-Nr: (USBII1903-54G)
Lieferant: US Biological
Hersteller Artikel Nummer : I1903-54G
Beschreibung: Anti-kappa light chain Goat Polyclonal Antibody (HRP (Horseradish Peroxidase))
UOM: 1 * 500 µG


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