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Image Unavailable-BOSSBS-6634R-A350

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Artikel-Nr: (BOSSBS-6634R-A350)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-A350
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-APOSPC3005-500G

Perfluoro-15-crown-5-ether 95%

Lieferant: Apollo Scientific
Beschreibung: Potential 19F NMR imaging agent, particularly effective in brain and spinal diagnostics, USP 4,838,274. Single nmr signal; liquid at room temperature.

Image Unavailable-BOSSBS-6634R-A750

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Artikel-Nr: (BOSSBS-6634R-A750)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-A750
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Product Image-620-1584

VWR® Traceable® Thermometer mit Großen Ziffern, Dreifachdisplay

Lieferant: VWR Collection
Beschreibung: Thermometer mit Display in Jumbo-Größe eignet sich zur Überwachung von Gefrierschränken, Wasserbädern, Heizblöcken, Inkubatoren und Kühlschränken. Der Fühler wird durch eine Flasche vor vorübergehenden Temperaturänderungen beim Öffnen der Gefrierschranktür geschützt. Lösung ist durch die FDA (Food and Drug Administration) als GRAS (Generally Recognised As Safe) eingestuft.

Product Image-SENA0096647495163

Module für AiroSensor X ER 20-20-43, Digital PT100 4-Drähte hermetisch versiegelter Temperaturfühler, Klasse A, 10 m (nur Fühler)

Artikel-Nr: (SENA0096647495163)
Lieferant: SenseAnywhere
Hersteller Artikel Nummer : 0096647495163
Beschreibung: Diese intelligente Sonde mit digitaler SenseAnywhere-Bus-Schnittstelle wurde speziell für die Messung extremer Temperaturen in flüssigen Substanzen entwickelt. Dank seiner hermetischen Versiegelung aus PFA, besser bekannt als Teflon®, weist die hermetisch versiegelte Pt100-Sonde eine hohe chemische Beständigkeit auf. Die Sonde ist dank ihrer PFA-Isolierung wasserdicht und leicht zu reinigen. Sie ist widerstandsfähig gegen aggressive Substanzen und kann daher Messungen in praktisch allen Flüssigkeiten durchführen, während sie ständig unter Wasser ist. Das PT100-Element hat eine Genauigkeit der Klasse A; die Messungen werden mit einem sehr hohen Genauigkeitsniveau durchgeführt.
UOM: 1 * 1 ST
Product Image-EBRO1340-6664

Temperature and Pressure Data Loggers for Process Validation, EBI 12-TP322 or -TP422

Lieferant: EBRO
Beschreibung: <p>Both data loggers are high-precision temperature and pressure loggers designed for process validation in steam sterilisers, batch control, and pharmaceutical applications. With a wide temperature and pressure range and high accuracy, they provide reliable data logging for critical monitoring processes in sterilisation, healthcare, production, and pharmaceutical environments, ensuring accurate validation and quality control.</p>

Image Unavailable-BOSSBS-6634R-FITC

Anti-XPC Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Artikel-Nr: (BOSSBS-6634R-FITC)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-FITC
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Product Image-620-1826

VWR® Traceable®, Digitalthermometer

Artikel-Nr: (620-1826)
Lieferant: VWR Collection
Beschreibung: Diese Thermometer ermöglichen die genaue Überwachung der Temperatur in Gefriergeräten, Kühlschränken, Brutschränken und Klimakammern. Flasche und Lösung isolieren den Messfühler bei vorübergehenden Temperaturänderungen.
Wasserdichter Fühler in Flasche mit ungiftigem Glykol.
UOM: 1 * 1 ST
Product Image-EBRO1340-6625

Robust Temperature Bottle Data Loggers, EBI 12-T46X

Lieferant: EBRO
Beschreibung: Dieser Datenlogger wurde für die Überwachung des Innen- und Außenbereichs von Flaschen oder Dosen entwickelt und ist für die Validierung von Herstellungsprozessen unverzichtbar. Die zentrale Axialsonde misst die Innentemperatur genau, während der seitliche Sensor die Außentemperatur der Verpackung erfasst. Die erfassten Daten ermöglichen eine genaue Analyse der Dauer der Temperaturbelastung. Dieser Logger ist für seine Langlebigkeit und hohe Genauigkeit bekannt und ein zuverlässiges Werkzeug in der Qualitätssicherung.

Product Image-620-2701

Temperatur-Funkdatenlogger, AiroSensor X ER 20-20-43, für ultratiefe Temperaturen (−200 bis + 200 °C)

Lieferant: SenseAnywhere
Beschreibung: Der SenseAnywhere AiroSensor X ER Modell 20-20-43 ist wie der beliebte AiroSensor T ER Modell 20-20-31, verfügt jedoch zusätzlich über einen IP67-Stecker mit dem digitalen SenseAnywhere Bus (SAB). Der SAB-Bus ist eine sehr vielseitige Schnittstelle, welche die Energie- und Datenkommunikation zu SAB-kompatiblen Peripheriegeräten von SenseAnywhere ermöglicht. Aufgrund der Beschaffenheit dieser Schnittstelle können die Peripheriegeräte als Einzelgerät getestet und kalibriert werden. Dies bietet einen großen Vorteil gegenüber analogen Schnittstellen, bei welchen Sensor und Messgerät immer paarweise kalibriert werden müssen. Einsetzbar in vielen Industrieanwendungen: Apotheken, Arzneimitteltransport, Gastgewerbe und Gesundheitswesen, Kühlkette, Labor, usw.

Image Unavailable-BOSSBS-6634R-A488

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Artikel-Nr: (BOSSBS-6634R-A488)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-A488
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6634R-CY7

Anti-XPC Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-6634R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-CY7
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6634R-A555

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-6634R-A555)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-A555
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6634R-CY5.5

Anti-XPC Rabbit Polyclonal Antibody (Cy5.5®)

Artikel-Nr: (BOSSBS-6634R-CY5.5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-CY5.5
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Product Image-620-1582

VWR® Traceable Plus, Thermometer mit Dreifachdisplay und großen Ziffern

Lieferant: VWR Collection
Beschreibung: Traceable Plus Digitalthermometer überwachen die Temperaturen in Gefrierschränken, Wasserbädern, Heizblöcken, Inkubatoren und Kühlschränken.

Product Image-710-1670

Nährmedienzubereiter, ProfiClave

Artikel-Nr: (710-1670)
Lieferant: BioTool
Hersteller Artikel Nummer : 620001
Beschreibung: Die Nährmedienzubereiter ProfiClave PC10B/20B ermöglichen die Zubereitung von bis zu 10/15 Litern einfacher oder komplexer, mit Vitamin/Blut ergänzter, Agarformulierungen. Schneller und einfacher als je zuvor. Dank der intuitiven intelligenten Software und des praktischen Touchscreens ist nur eine kurze, schnelle Schulung in der Verwendung der Nährmedienzubereiter notwendig. Der ProfiClave PC20 ermöglicht die Zubereitung von 1 bis 15 Litern Agar, der ProfiClave PC10 von 0,5 bis10 Litern, mit Rührfunktion und Temperaturregelung. Der Zugang zum Behälter ist sehr einfach, es sind keine Schrauben oder Werkzeug erforderlich. Verbesserte Programmierbarkeit (3×20 Programme), Betriebsparameter-Ausdruck (integriert an der Gerätevorderseite), externe Steuerfunktionen (Anschluss an der Gerätevorderseite), optimale Rührkontrolle und ein Gehäuse komplett aus Metall machen den ProfiClave zum besten Nährmedienzubereiter in seiner Klasse. Er hält das Agar in jeder Phase des Einzel- oder Doppelzyklus-Prozesses bei der erforderlichen Temperatur, falls nötig für Stunden. Der Wassermantel-Design ermöglicht eine gleichmäßige Wärmeverteilung innerhalb des Behälters. Rührer mit unterschiedlichen Geschwindigkeiten und eine verbesserte Magnetkupplung ohne Dichtungen oder Schächte.
UOM: 1 * 1 ST
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