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Image Unavailable-BOSSBS-6634R-A647

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Artikel-Nr: (BOSSBS-6634R-A647)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-A647
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-IMECG2H-000

tempmate.®-GS2 Single-Use Temperature Data Logger

Artikel-Nr: (IMECG2H-000)
Lieferant: tempmate
Hersteller Artikel Nummer : G2H-000
Beschreibung: <p>The tempmate.®-GS2 offers you the possibility to perform the worldwide* real-time monitoring of all relevant data. By setting individual alarm limits, you are alerted in real-time. Damage can therefore be clearly localised and identified. With continuous use, you can optimise your transport routes and internal processes.</p>
UOM: 1 * 1 ST

New Product


Product Image-VACU20636155

Vakuum-Messgeräte-Sets DCP 3000 und VSP 3000

Lieferant: VACUUBRAND
Beschreibung: Das DCP 3000 ist ein leistungsstarkes Vakuum-Messgerät mit großem beleuchtetem Display. Der neuartige Vakuumsensor VSP 3000 basiert auf der Gaswärmeleitung (Pirani) für den weiten Messbereich von Atmosphärendruck bis hinunter auf 10-3 mbar. Alle Teile, die mit Flüssigkeiten in Kontakt kommen, sind aus chemikalienbeständigen Kunststoffen (PBT, PUR) und Aluminiumoxidkeramik gefertigt. Das Gerät bietet eine deutlich höhere chemische Beständigkeit und Robustheit als übliche Pirani-Sensoren mit filigraner Metallwendel. Bis zu acht Vakuumsensoren lassen sich gleichzeitig anschließen und ermöglichen so flexible Messungen vor Ort. Das DCP 3000 kommuniziert mit externen Komponenten über das digitale Bus-System VACUU·BUS®. Dieses zeichnet sich durch eine vollständig automatische Konfiguration, einheitliche Steckerverbindungen und Kabellängen von bis zu 30 m aus. Darüber hinaus bietet das DCP 3000 relative Druckmessungen (VSK 3000 als Referenz) und Datenprotokollierung von bis zu 32000 Datenwerten.

Environmentally Preferable

Product Image-THBRSV603-500-LSB

Drahtloses Überwachungssystem, Smart-Vue

Lieferant: Thermo Fisher Scientific
Beschreibung: Überwachung Ihrer Arbeitsumgebungen oder Laborgeräte

Image Unavailable-MMMADT-1135E

Particulate Filter, DT

Artikel-Nr: (MMMADT-1135E)
Lieferant: 3M
Hersteller Artikel Nummer : DT-1135E
Beschreibung: For effective protection against a range of particulates, gases and vapours or combination hazards, use 3M™ filters DT-Series. Suitable for use with certain 3M™ half and full-face tight-fitting respirators in negative-pressure mode as well as 3M™ powered air respirator system PF-600E+ series.
UOM: 1 * 10 ST
Image Unavailable-BOSSBS-6634R-A750

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Artikel-Nr: (BOSSBS-6634R-A750)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-A750
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-42757.18

Kieselgel 60 0.060-0.2mm (70-230 mesh), mit fluoreszierendem Indikator

Lieferant: Thermo Fisher Scientific
Beschreibung: Silica gel 60 is used as carriers, processing aids, anti-caking and free-flow agents in animal feed. Defoamer applications such as paint, food, paper, textile and other industrial applications. Synthetic silicon dioxides are used as a rheology control agent in plastics. It is also used in dry column chromatography without applied pressure (gravity pulled).

Sicherheitsdatenblätter Zertifikate

Product Image-181-0309

VWR® VCP 80/VCP 130 Vacuum/Pressure Pumps

Lieferant: VWR Collection
Beschreibung: VCP 80 und VCP 130 können als Vakuum- und Druckpumpen verwendet werden und setzen Standards bei der effizienten Vakuumnutzung. Mit diesen Pumpen kann ein erschwingliches Vakuum für Anwendungen, bei denen Korrosionsbeständigkeit nicht erforderlich ist, erzielt werden. Die Pumpen können für die Vakuumfiltration von wässrigen Lösungen oder wässrigen Dämpfen, einschließlich Puffern, verwendet werden. Allerdings werden sie nicht zum Pumpen saurer, basischer oder organischer Dämpfe empfohlen. Die Vakuum-/Druckpumpen der VWR® Collection sind für den unbeaufsichtigten Dauerbetrieb ausgelegt und haben zwei Manometer mit manuellen Reglern zur einfachen Überwachung des erforderlichen Vakuums oder Drucks.

Sale

Product Image-BRDY150759

BradyJet™ J2000 Safety Marine Labels, White

Lieferant: Brady
Beschreibung: The British standard BS 5609 sets durability criteria for printed pressure-sensitive, adhesive-coated labels used when shipping chemical drums by sea.

Product Image-620-2632

VWR®, USB Datenlogging Barometer, Traceable® Memory Loc

Artikel-Nr: (620-2632)
Lieferant: VWR Collection
Beschreibung: Das VWR® Traceable® Memory Loc Barometer mit Datenlogger und USB-Schnittstelle überwacht gleichzeitig Luftdruck, Temperatur und Luftfeuchtigkeit. Das Gerät kann in Umgebungen verwendet werden, die 21 CFR 11 entsprechen müssen.
UOM: 1 * 1 ST
Image Unavailable-BOSSBS-6634R-A680

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Artikel-Nr: (BOSSBS-6634R-A680)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-A680
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-VERNAPW00064

Schläuche, Tygon®, A-60-F IB

Lieferant: Saint Gobain Life Sciences
Beschreibung: Tygon® A-60-F IB is a reinforcement embedded tubing within its walls to withstand elevated pressure and to withstand extreme temperatures from –24 to 135 °C. It will not crack or deteriorate when used in demanding food and beverage applications.

Image Unavailable-BOSSBS-6634R-A488

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Artikel-Nr: (BOSSBS-6634R-A488)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-A488
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6634R-CY7

Anti-XPC Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-6634R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6634R-CY7
Beschreibung: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0356R-CY3

Anti-NOS3 Rabbit Polyclonal Antibody (Cy3®)

Artikel-Nr: (BOSSBS-0356R-CY3)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-0356R-CY3
Beschreibung: Digoxin is a beta blocker drug originally derived from the foxglove plant, Digitalis lanata. Digoxin is used primarily to improve the pumping ability of the heart in congestive heart failure (CHF), and treat problems such as high blood pressure. It is also used to help normalize some dysrhythmias (abnormal types of heartbeat).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0356R-CY7

Anti-NOS3 Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-0356R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-0356R-CY7
Beschreibung: Digoxin is a beta blocker drug originally derived from the foxglove plant, Digitalis lanata. Digoxin is used primarily to improve the pumping ability of the heart in congestive heart failure (CHF), and treat problems such as high blood pressure. It is also used to help normalize some dysrhythmias (abnormal types of heartbeat).
UOM: 1 * 100 µl
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