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Anti-CDKN1A Mouse Monoclonal Antibody (CF640R) [clone: WA-1]

Lieferant: Biotium
Beschreibung: This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma). In ELISA, MAb WA-1 is useful either as a solid phase or for detection of p21 protein.

Image Unavailable-BOSSBS-5344R-A647

Anti-ECT2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Artikel-Nr: (BOSSBS-5344R-A647)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5344R-A647
Beschreibung: The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. [provided by RefSeq].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9143R-A488

Anti-ZNF230 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Artikel-Nr: (BOSSBS-9143R-A488)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-9143R-A488
Beschreibung: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF141 (ring finger protein 141), also known as ZFP26 or ZNF230, is a 230 amino acid protein that contains one RING-type zinc finger. Expressed as two isoforms (isoform 1 and isoform 2) due to alternative splicing events, RNF141 is thought to function as a transcription factor during spermatogenesis. While isoform 2 is expressed in brain, heart, pancreas, kidney and skeletal muscle, isoform 1 is expressed primarily in testis, suggesting that isoform 1 functions during spermatogenesis. In addition, RNF141 is not expressed in azoospermic (infertile) men, further implicating an important role for RNF141 in testis development and male fertility.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9143R-CY3

Anti-ZNF230 Rabbit Polyclonal Antibody (Cy3®)

Artikel-Nr: (BOSSBS-9143R-CY3)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-9143R-CY3
Beschreibung: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF141 (ring finger protein 141), also known as ZFP26 or ZNF230, is a 230 amino acid protein that contains one RING-type zinc finger. Expressed as two isoforms (isoform 1 and isoform 2) due to alternative splicing events, RNF141 is thought to function as a transcription factor during spermatogenesis. While isoform 2 is expressed in brain, heart, pancreas, kidney and skeletal muscle, isoform 1 is expressed primarily in testis, suggesting that isoform 1 functions during spermatogenesis. In addition, RNF141 is not expressed in azoospermic (infertile) men, further implicating an important role for RNF141 in testis development and male fertility.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12173R-A680

Anti-KCNF1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Artikel-Nr: (BOSSBS-12173R-A680)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-12173R-A680
Beschreibung: KCNF1 is a multi-pass membrane-bound protein that acts as an ion channel and is generally expressed as a heterotetramer of potassium channeling proteins. Formerly known as kH1, KCNF1 is usually found as a heteromer with three other potassium channel proteins, KCNG3, KV6.3 and KCNV2. As a potassium channel protein, KCNF1 plays a role in regulating apoptosis and proliferation of pulmonary artery smooth muscle (PASM) cells. Bone morphogenetic proteins (BMPs) restrict proliferation and can induce apoptosis in normal human PASM cells and will upregulate expression of KCNF1 in PASM cells in vitro. KCNF1 is expressed in heart, brain, liver, skeletal muscle, kidney and pancreas.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12173R-HRP

Anti-KCNF1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Artikel-Nr: (BOSSBS-12173R-HRP)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-12173R-HRP
Beschreibung: KCNF1 is a multi-pass membrane-bound protein that acts as an ion channel and is generally expressed as a heterotetramer of potassium channeling proteins. Formerly known as kH1, KCNF1 is usually found as a heteromer with three other potassium channel proteins, KCNG3, KV6.3 and KCNV2. As a potassium channel protein, KCNF1 plays a role in regulating apoptosis and proliferation of pulmonary artery smooth muscle (PASM) cells. Bone morphogenetic proteins (BMPs) restrict proliferation and can induce apoptosis in normal human PASM cells and will upregulate expression of KCNF1 in PASM cells in vitro. KCNF1 is expressed in heart, brain, liver, skeletal muscle, kidney and pancreas.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5966R-A750

Anti-LMO4 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Artikel-Nr: (BOSSBS-5966R-A750)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5966R-A750
Beschreibung: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterised by a conserved LIM domain (1). The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation (2). LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons (3). LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI) (4). NLI, known also as CLIM-1, and the related protein CLIM-2 facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins (5). LMO2 and the related protein LMO4 are expressed in thymic precursor cells (6). LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors (7).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11868R-A647

Anti-LDB1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Artikel-Nr: (BOSSBS-11868R-A647)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-11868R-A647
Beschreibung: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation. LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI). NLI, known also as CLIM-1, and the related protein CLIM-2, facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins. LMO2 and the related protein LMO4 are expressed in thymic precursor cells. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11868R-A680

Anti-LDB1/CLIM-2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Artikel-Nr: (BOSSBS-11868R-A680)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-11868R-A680
Beschreibung: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterised by a conserved LIM domain. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation. LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI). NLI, known also as CLIM-1, and the related protein CLIM-2, facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins. LMO2 and the related protein LMO4 are expressed in thymic precursor cells. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5966R-A555

Anti-LMO4 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-5966R-A555)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5966R-A555
Beschreibung: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain (1). The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation (2). LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons (3). LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI) (4). NLI, known also as CLIM-1, and the related protein CLIM-2 facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins (5). LMO2 and the related protein LMO4 are expressed in thymic precursor cells (6). LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors (7).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6264R-A555

Anti-EMP2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-6264R-A555)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6264R-A555
Beschreibung: EMP-2 is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5415R-A750

Anti-Tau protein Ser721 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Artikel-Nr: (BOSSBS-5415R-A750)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5415R-A750
Beschreibung: Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilisation. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-10112R-A680

Anti-Tau protein Thr529 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Artikel-Nr: (BOSSBS-10112R-A680)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-10112R-A680
Beschreibung: Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localisation (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilisation. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-10116R-A750

Anti-Tau protein Ser519 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Artikel-Nr: (BOSSBS-10116R-A750)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-10116R-A750
Beschreibung: Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localisation (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilisation. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5473R-A680

Anti-Tau protein Ser416 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Artikel-Nr: (BOSSBS-5473R-A680)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5473R-A680
Beschreibung: Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilisation. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11163R-CY5

Anti-SPRR3 Rabbit Polyclonal Antibody (Cy5®)

Artikel-Nr: (BOSSBS-11163R-CY5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-11163R-CY5
Beschreibung: Esophagin, also known as small proline-rich protein 3 (SPR3) or Cornifin ∫, belongs to the cornifin family of cornified-envelope structural proteins. It is expressed in mucosal epithelia such as esophagus and tongue and is strongly induced during epidermal keratinocyte differentiation. Due to its highly inducible nature, Esophagin is considered a marker of squamous differentiation. Esophagin serves as a cross-linking protein within the cornified cell envelope and may play a role in the maintenance of normal esophageal epithelial homeostasis. It shares significant homology with the related proteins, SPRR1 and SPRR2. Esophagin is typically not expressed in healthy human epithelium, but its expression is upregulated in numerous hyperproliferative disorders of the skin. Contrastly, its expression is dramatically downregulated in esophageal squamous cell carcinoma.
UOM: 1 * 100 µl
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