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Image Unavailable-PRSI91-729

Human recombinant sialate O-Acetylesterase (from cells)

Artikel-Nr: (PRSI91-729)
Lieferant: ProSci Inc.
Hersteller Artikel Nummer : 91-729
Beschreibung: Sialate O-Acetylesterase (SIAE) belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. SIAE is widely expressed with high expression levels in the testis, prostate, and colon. SIAE catalyses N-acetyl-O-acetylneuraminate and H2O to N-acetylneuraminate and acetate. SIAE removes O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. SIAE down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance. Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.
UOM: 1 * 50 µG
Image Unavailable-PRSI92-137

Human recombinant sialic acid synthase (from E. coli)

Artikel-Nr: (PRSI92-137)
Lieferant: ProSci Inc.
Hersteller Artikel Nummer : 92-137
Beschreibung: Sialic Acid Synthase (NANS) is an enzyme that contains one AFP-like domain. NANS is ubiquitous and plays a role in the biosynthetic pathways of sialic acids. NANS produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). It also can use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
UOM: 1 * 50 µG

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N-Acetyl-β-D-mannosamine hydrate ~95%, weißes Pulver

Lieferant: MP Biomedicals
Beschreibung: N-Acetyl-β-D-mannosamine hydrate is used as a substrate to identify, differentiate and characterise enzymes such as N-acetyl-glucosamine epimerase(s) and aldolase(s). N-Acetyl-D-mannosamine is used for the synthesis of of N-acetylneuraminic acid.

Product Image-PRSI26-355

Anti-CMAS Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI26-355)
Lieferant: ProSci Inc.
Hersteller Artikel Nummer : 26-355
Beschreibung: CMAS is an enzyme that catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.The enzyme encoded by this gene catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.
UOM: 1 * 50 µG
Product Image-PRSI26-232

Anti-ST6GALNAC1 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI26-232)
Lieferant: ProSci Inc.
Hersteller Artikel Nummer : 26-232
Beschreibung: Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins.Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).
UOM: 1 * 50 µG
Product Image-PRSI56-322

Anti-GNE Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI56-322)
Lieferant: ProSci Inc.
Hersteller Artikel Nummer : 56-322
Beschreibung: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq].
UOM: 1 * 400 µl

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Product Image-PRSI56-398

Anti-ST6GALNAC1 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI56-398)
Lieferant: ProSci Inc.
Hersteller Artikel Nummer : 56-398
Beschreibung: Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).
UOM: 1 * 400 µl

New Product


Product Image-PRSI5169

Anti-ST3GAL6 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI5169)
Lieferant: ProSci Inc.
Hersteller Artikel Nummer : 5169
Beschreibung: ST3gal6 Antibody: Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types. However, cancer cells often express more heavily sialylated glycans on their cell surface and this feature sometimes correlates with invasiveness. In contrast, expression of ST3gal6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, was found to be significantly decreased by hypermethylation of the gene in gastrointestinal cancer. At least three isoforms of ST3gal6 are known to exist.
UOM: 1 * 100 µG
Product Image-PRSIXW-8145

Anti-ST8SIA1 Chicken Polyclonal Antibody

Artikel-Nr: (PRSIXW-8145)
Lieferant: ProSci Inc.
Hersteller Artikel Nummer : XW-8145
Beschreibung: FUNCTION: Involved in the production of GD3 and GT3 from GM3.
CATALYTIC ACTIVITY: CMP-N-acetylneuraminate + beta-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + beta-N-acetylneuraminyl-2,8-beta-N-acetylneuraminyl-2,3-beta-D-galactosyl-R.
SIMILARITY: Belongs to the glycosyltransferase 29 family.
PATHWAY: Glycosylation.
SUBCELLULAR LOCATION: Golgi apparatus; Golgi membrane; single-pass type II membrane protein
UOM: 1 * 50 µG
Product Image-1.06044.9030

Dichlormethan stabilisiert, LiChrosolv® für die HPLC, Supelco®

Lieferant: Merck
Beschreibung: With their high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level, LiChrosolv® solvents are ideal for reproducible separations. Since separations are normally carried out under gradient conditions in analytical HPLC, we offer solvents in 'gradient grade' as well as 'isocratic grade'. This minimises the gradient effect of the solvent involved.

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Product Image-1.00030.4000

Acetonitril ≥99,9%, LiChrosolv® Reag. Ph. Eur., Gradienten-Qualität für die Flüssigchromatographie, Supelco®

Lieferant: Merck
Beschreibung: Mit ihrer hohen UV-Durchlässigkeit und niedrigen Partikelanzahl und ihrem geringen Säure- und Basengehalt sowie geringen Verdampfungsrückständen eignen sich LiChrosolv® Lösungsmittel ideal für reproduzierbare Trennungen. Da Trennungen in der analytischen HPLC normalerweise unter Gradientenbedingungen stattfinden, bieten wir Lösungsmittel sowohl in der Güteklasse „Gradient Grade“ als auch in „Isocratic Grade“ und damit eine Möglichkeit, den Gradienteneffekt des beteiligten Lösungsmittels auf ein Minimum zu reduzieren.

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Image Unavailable-1.11727.0500

E/E ≥99,9% (durch GC), LiChrosolv®, Gradienten-Qualität für die Flüssigchromatographie, Supelco®

Lieferant: Merck
Beschreibung: With their high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level, LiChrosolv® solvents are ideal for reproducible separations. Since separations are normally carried out under gradient conditions in analytical HPLC, we offer solvents in 'gradient grade' as well as 'isocratic grade'. This minimises the gradient effect of the solvent involved.

Sicherheitsdatenblätter Zertifikate Sale

Product Image-1.06007.4000

Methanol ≥99,9% (durch GC), LiChrosolv® Reag. Ph. Eur., Gradienten-Qualität für die Flüssigchromatographie, Supelco®

Lieferant: Merck
Beschreibung: With their high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level, LiChrosolv® solvents are ideal for reproducible separations. Since separations are normally carried out under gradient conditions in analytical HPLC, we offer solvents in "gradient grade" as well as "isocratic grade". This enables to minimize the gradient effect of the solvent involved.

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Image Unavailable-276235-1G

3-Noradamantanecarboxylic acid 97%

Artikel-Nr: (276235-1G)
Lieferant: SIGMA ALDRICH MICROSCOPY
Hersteller Artikel Nummer : 276235-1G
Beschreibung: Building block for 'Anti-Bredt' strained molecules.
UOM: 1 * 1 g
Image Unavailable-1.07222.1000

Peracetic acid ∼38 - 40%, Supelco®

Artikel-Nr: (1.07222.1000)
Lieferant: Merck
Hersteller Artikel Nummer : 1.07222.1000
Beschreibung: Peracetic acid ∼38 - 40%, Supelco®
UOM: 1 * 1 L

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Image Unavailable-309052-25G

Quinoline yellow sulphonic acid sodium salt (Acid yellow 3), Sigma-Aldrich®

Artikel-Nr: (309052-25G)
Lieferant: SIGMA ALDRICH MICROSCOPY
Hersteller Artikel Nummer : 309052-25G
Beschreibung: Quinoline Yellow, Mixture of the mono- and disulfonic acids of Quinoline Yellow (Acid Yellow 3)
UOM: 1 * 25 g

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