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Image Unavailable-BOSSBS-11772R

Anti-Tetanus Toxin heavy chain Rabbit Polyclonal Antibody

Artikel-Nr: (BOSSBS-11772R)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-11772R
Beschreibung: Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2. The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3907R-A555

Anti-LGMN Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-3907R-A555)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-3907R-A555
Beschreibung: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6239R-CY5

Anti-SH3KBP1 Rabbit Polyclonal Antibody (Cy5®)

Artikel-Nr: (BOSSBS-6239R-CY5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6239R-CY5
Beschreibung: SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6239R-A488

Anti-SH3KBP1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Artikel-Nr: (BOSSBS-6239R-A488)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6239R-A488
Beschreibung: SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6239R-A350

Anti-SH3KBP1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Artikel-Nr: (BOSSBS-6239R-A350)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6239R-A350
Beschreibung: SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3907R-A680

Anti-Legumain Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Artikel-Nr: (BOSSBS-3907R-A680)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-3907R-A680
Beschreibung: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7877R-CY7

Anti-NEDD4 Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-7877R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-7877R-CY7
Beschreibung: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
UOM: 1 * 100 µl
Image Unavailable-C5548-100MG

Clobetasone butyrate ≥98%

Artikel-Nr: (C5548-100MG)
Lieferant: SIGMA ALDRICH MICROSCOPY
Hersteller Artikel Nummer : C5548-100MG
Beschreibung: Clobetasone butyrate is a corticosteroid. It can be used as a diagnostic assay manufacturing, hematology, histology. Clobetasone butyrate has been used as an internal standard for the quantitative assay of clobetasol propionate. Clobetasone butyrate has been used to analyse its bio-concentration factor (BCF) in cyprinus carpio. Clobetasone butyrate is a potent topical corticosteroid and is primarily used to treat atopic dermatitis (AD). Low dosage of this drug is used to treat dry eye in sjogrens syndrome.
UOM: 1 * 100 mg
Image Unavailable-BOSSBS-13359R

Anti-KCNJ3 Rabbit Polyclonal Antibody

Artikel-Nr: (BOSSBS-13359R)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-13359R
Beschreibung: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5883R-A647

Anti-SLC9A3R1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Artikel-Nr: (BOSSBS-5883R-A647)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5883R-A647
Beschreibung: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3299R-CY5.5

Anti-NEDD4L Rabbit Polyclonal Antibody (Cy5.5®)

Artikel-Nr: (BOSSBS-3299R-CY5.5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-3299R-CY5.5
Beschreibung: E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5883R-A350

Anti-SLC9A3R1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Artikel-Nr: (BOSSBS-5883R-A350)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5883R-A350
Beschreibung: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6672R-CY5.5

Anti-KCNJ3 Rabbit Polyclonal Antibody (Cy5.5®)

Artikel-Nr: (BOSSBS-6672R-CY5.5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6672R-CY5.5
Beschreibung: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6672R-A555

Anti-KCNJ3 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-6672R-A555)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6672R-A555
Beschreibung: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2162R-CY5

Anti-DKK1 Rabbit Polyclonal Antibody (Cy5®)

Artikel-Nr: (BOSSBS-2162R-CY5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-2162R-CY5
Beschreibung: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2162R-CY3

Anti-DKK1 Rabbit Polyclonal Antibody (Cy3®)

Artikel-Nr: (BOSSBS-2162R-CY3)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-2162R-CY3
Beschreibung: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
UOM: 1 * 100 µl
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