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Image Unavailable-BOSSBS-6239R-CY7

Anti-SH3KBP1 Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-6239R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6239R-CY7
Beschreibung: SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13164R-HRP

Anti-FLNA Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Artikel-Nr: (BOSSBS-13164R-HRP)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-13164R-HRP
Beschreibung: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
UOM: 1 * 100 µl
Image Unavailable-PRSI91-739

Human recombinant ribonuclease Pancreatic (from cells)

Artikel-Nr: (PRSI91-739)
Lieferant: ProSci Inc.
Hersteller Artikel Nummer : 91-739
Beschreibung: Ribonuclease Pancreatic is a secreted enzyme that belongs to the pancreatic ribonuclease family. RNASE1 is an endonuclease that cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. RNASE1 prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. RNASE1 acts on single stranded and double stranded RNA.
UOM: 1 * 50 µG
Image Unavailable-BOSSBS-13164R-A350

Anti-FLNA Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Artikel-Nr: (BOSSBS-13164R-A350)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-13164R-A350
Beschreibung: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1243R-A350

Anti-TROP2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Artikel-Nr: (BOSSBS-1243R-A350)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1243R-A350
Beschreibung: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1243R-CY5.5

Anti-TROP2 Rabbit Polyclonal Antibody (Cy5.5®)

Artikel-Nr: (BOSSBS-1243R-CY5.5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1243R-CY5.5
Beschreibung: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1243R-CY7

Anti-TROP2 Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-1243R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1243R-CY7
Beschreibung: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1243R-A488

Anti-TROP2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Artikel-Nr: (BOSSBS-1243R-A488)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1243R-A488
Beschreibung: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7877R-CY5.5

Anti-NEDD4 Rabbit Polyclonal Antibody (Cy5.5®)

Artikel-Nr: (BOSSBS-7877R-CY5.5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-7877R-CY5.5
Beschreibung: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
UOM: 1 * 100 µl
Image Unavailable-SPCMC1366-2.5KG

Croscarmellose sodium NF

Lieferant: Spectrum Chemical
Beschreibung: CROSCARMELLOSE SODIUM, NF is an internally crosslinked sodium carboxymethylcellulose. Croscarmellose Sodium, NF is used commonly as a FDA-approved disintegrant in pharmaceutical manufacturing. The cross linking minimizes its solubility in water while allowing it to absorb many times its weight in water like a sponge.

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Image Unavailable-BOSSBS-7877R-A555

Anti-NEDD4 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-7877R-A555)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-7877R-A555
Beschreibung: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6672R-A488

Anti-KCNJ3 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Artikel-Nr: (BOSSBS-6672R-A488)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6672R-A488
Beschreibung: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3299R-CY3

Anti-NEDD4L Rabbit Polyclonal Antibody (Cy3®)

Artikel-Nr: (BOSSBS-3299R-CY3)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-3299R-CY3
Beschreibung: E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5883R

Anti-SLC9A3R1 Rabbit Polyclonal Antibody

Artikel-Nr: (BOSSBS-5883R)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5883R
Beschreibung: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7877R-HRP

Anti-NEDD4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Artikel-Nr: (BOSSBS-7877R-HRP)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-7877R-HRP
Beschreibung: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3299R-A488

Anti-NEDD4L Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Artikel-Nr: (BOSSBS-3299R-A488)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-3299R-A488
Beschreibung: E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.
UOM: 1 * 100 µl
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