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Image Unavailable-BOSSBS-6124R-A680

Anti-p95 NBS1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Artikel-Nr: (BOSSBS-6124R-A680)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6124R-A680
Beschreibung: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Product Image-113-7882

VWR®, Reinraum-Overalls

Lieferant: VWR Collection
Beschreibung: These sterile, single-use overalls are made of breathable SMS fabric. They are ideal for use in cleanroom production and research.

Zertifikate

Product Image-ENZOENZ42813

Bio-16-ddUTP, tetralithium salt

Artikel-Nr: (ENZOENZ42813)
Lieferant: ENZO LIFE SCIENCES
Hersteller Artikel Nummer : ENZ42813
Beschreibung: Bio-16-ddUTP (Biotin-16-2’,3’-dideoxyuridine-5’-triphosphate) can be used for 3’-end labelling of single-stranded or double-stranded DNA. It is especially useful as a substrate for terminal transferase for the 3’-terminal addition of a single Bio-16-ddUMP. Biotin-labelled oligonucleotides produced by this reaction are suitable as hybridisation probes and nucleic acid array assays. It is also a substrate for Taq DNA polymerase and other DNA polymerases.
UOM: 1 * 25 Nmo
Image Unavailable-BOSSBS-6124R-CY5

Anti-NBN Rabbit Polyclonal Antibody (Cy5®)

Artikel-Nr: (BOSSBS-6124R-CY5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6124R-CY5
Beschreibung: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6124R-A488

Anti-NBN Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Artikel-Nr: (BOSSBS-6124R-A488)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6124R-A488
Beschreibung: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6124R-CY3

Anti-NBN Rabbit Polyclonal Antibody (Cy3®)

Artikel-Nr: (BOSSBS-6124R-CY3)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6124R-CY3
Beschreibung: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Product Image-662-0751

Filling solutions for pH electrodes, Orion™

Lieferant: Thermo Orion
Beschreibung: Filling solutions for pH and reference electrodes.

Sicherheitsdatenblätter

Product Image-UPCHP-450

Mikro-Splitterventil, Upchurch Scientific®

Artikel-Nr: (UPCHP-450)
Lieferant: UPCHURCH SCIENTIFIC
Hersteller Artikel Nummer : P-450
Beschreibung: Entwickelt für die genaue Teilung und Regelung eines Low-Flow-Durchflusses einer einzelnen eingehenden Versorgung.
UOM: 1 * 1 ST
Product Image-300-0256

Einweg-Probenehmer, PowderDispo

Lieferant: BURKLE
Beschreibung: Einweg-Probenehmer bieten höchste Standards bei der Probenahme und müssen nach Gebrauch nicht gereinigt werden.

Zertifikate

Product Image-BURK5393-8030

PharmaDispo Einweg-Pulverprobenehmer

Lieferant: BURKLE
Beschreibung: Der Einweg-Pulverprobenehmer PharmaDispo ist ein Mehrfach-Zielpunktprobenehmer für den Einmalgebrauch, der mit einer Probenahme drei separate Zielpunktproben entnimmt.

New Product

Product Image-734-2966

VWR®, Einzelwell-Zellkulturplatten

Lieferant: VWR Collection
Beschreibung: Einzelwell-Zellkulturplatten aus transparentem PS sind in plasmabehandelter Ausführung für konsistente Zellhaftung und optimales Wachstum erhältlich, oder in unbehandelter Ausführung für Anwendungen, in denen keine Zellanhaftung gewünscht ist.

Zertifikate Environmentally Preferable

Product Image-300-0247

Einweg-Probenehmer, MultiDispo

Lieferant: BURKLE
Beschreibung: Dieser MultiDispo Einweg-Probenehmer ist ideal für die Probenahme aus mehreren Schichten des Probengutes.

Zertifikate Environmentally Preferable

Image Unavailable-BOSSBS-6124R-A555

Anti-NBN Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-6124R-A555)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6124R-A555
Beschreibung: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6124R-CY7

Anti-NBN Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-6124R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-6124R-CY7
Beschreibung: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Product Image-BOHLP1720-16

Temperatursonden, Lemo®, BOLA

Lieferant: Bohlender
Beschreibung: Wird zur Temperaturmessung in aggressiven Flüssigkeiten verwendet. Das Kabel ermöglicht eine flexible Verbindung vom Messgerät zum Medium.

Product Image-662-1532

Combination pH electrode, Orion™ Sure-Flow™ 9165BNWP

Artikel-Nr: (662-1532)
Lieferant: Thermo Orion
Hersteller Artikel Nummer : 9165BNWP
Beschreibung: Combination pH electrode with epoxy body for fast response in difficult samples and soils.
UOM: 1 * 1 ST
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das call noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 044 745 13 13.
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