Sie suchten nach: Cytosin

Artikel-Nr: (ENZOALX480096M005)

Lieferant: ENZO LIFE SCIENCES

Hersteller Artikel Nummer : ALX480096M005

Beschreibung: DNA methyltransferase inhibitor

UOM: 1 * 5 mg

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Artikel-Nr: (BOSSBS-5915R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-5915R-A750

Beschreibung: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalise with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both <i>in vivo</i> and <i>in vitro</i>. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6240R-A680)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-6240R-A680

Beschreibung: TLX3 (HOX11L2, RNX) belongs to a family of orphan homeobox genes that encode DNA binding nuclear transcription factors. Members of the HOX11 gene family are characterised by a threonine 47 replacing cytosine in the highly conserved homeodomain. This transcription factor is required for hematopoiesis. It is overexpressed in childhood acute lumphoblastic leukemia.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5376R-A680)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-5376R-A680

Beschreibung: May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6240R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-6240R-CY3

Beschreibung: TLX3 (HOX11L2, RNX) belongs to a family of orphan homeobox genes that encode DNA binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine 47 replacing cytosine in the highly conserved homeodomain. This transcription factor is required for hematopoiesis. It is overexpressed in childhood acute lumphoblastic leukemia.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9450R-CY5.5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-9450R-CY5.5

Beschreibung: Cytidine is a nucleoside formed by a cytosine attached to a ribose ring via a beta-N1-glycosidic bond. DNA is methylated on cytidines by DNA methylases (DNMTs)to generate 5-methylcytidine (5-mC), a potent epigenetics marker and regulator of gene expression. The reverse reaction (cytidine demethylation) starts with its oxidation to hydroxymethyl- (5-hmC), formyl- (5-fC), and carboxy- (5-caC) cytidine. Several enzymes, including the Tet family of proteins have been implicated in cytidine demethylation.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5749R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-5749R

Beschreibung: Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9450R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-9450R-CY3

Beschreibung: Cytidine is a nucleoside formed by a cytosine attached to a ribose ring via a beta-N1-glycosidic bond. DNA is methylated on cytidines by DNA methylases (DNMTs)to generate 5-methylcytidine (5-mC), a potent epigenetics marker and regulator of gene expression. The reverse reaction (cytidine demethylation) starts with its oxidation to hydroxymethyl- (5-hmC), formyl- (5-fC), and carboxy- (5-caC) cytidine. Several enzymes, including the Tet family of proteins have been implicated in cytidine demethylation.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6240R-CY5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-6240R-CY5

Beschreibung: TLX3 (HOX11L2, RNX) belongs to a family of orphan homeobox genes that encode DNA binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine 47 replacing cytosine in the highly conserved homeodomain. This transcription factor is required for hematopoiesis. It is overexpressed in childhood acute lumphoblastic leukemia.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-6240R-A647)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-6240R-A647

Beschreibung: TLX3 (HOX11L2, RNX) belongs to a family of orphan homeobox genes that encode DNA binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine 47 replacing cytosine in the highly conserved homeodomain. This transcription factor is required for hematopoiesis. It is overexpressed in childhood acute lumphoblastic leukemia.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-6240R-A488)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-6240R-A488

Beschreibung: TLX3 (HOX11L2, RNX) belongs to a family of orphan homeobox genes that encode DNA binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine 47 replacing cytosine in the highly conserved homeodomain. This transcription factor is required for hematopoiesis. It is overexpressed in childhood acute lumphoblastic leukemia.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-6240R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-6240R-A750

Beschreibung: TLX3 (HOX11L2, RNX) belongs to a family of orphan homeobox genes that encode DNA binding nuclear transcription factors. Members of the HOX11 gene family are characterised by a threonine 47 replacing cytosine in the highly conserved homeodomain. This transcription factor is required for hematopoiesis. It is overexpressed in childhood acute lumphoblastic leukemia.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-9450R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-9450R-A750

Beschreibung: Cytidine is a nucleoside formed by a cytosine attached to a ribose ring via a beta-N1-glycosidic bond. DNA is methylated on cytidines by DNA methylases (DNMTs)to generate 5-methylcytidine (5-mC), a potent epigenetics marker and regulator of gene expression. The reverse reaction (cytidine demethylation) starts with its oxidation to hydroxymethyl- (5-hmC), formyl- (5-fC), and carboxy- (5-caC) cytidine. Several enzymes, including the Tet family of proteins have been implicated in cytidine demethylation.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-9450R-A488)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-9450R-A488

Beschreibung: Cytidine is a nucleoside formed by a cytosine attached to a ribose ring via a beta-N1-glycosidic bond. DNA is methylated on cytidines by DNA methylases (DNMTs)to generate 5-methylcytidine (5-mC), a potent epigenetics marker and regulator of gene expression. The reverse reaction (cytidine demethylation) starts with its oxidation to hydroxymethyl- (5-hmC), formyl- (5-fC), and carboxy- (5-caC) cytidine. Several enzymes, including the Tet family of proteins have been implicated in cytidine demethylation.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-9450R-CY5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-9450R-CY5

Beschreibung: Cytidine is a nucleoside formed by a cytosine attached to a ribose ring via a beta-N1-glycosidic bond. DNA is methylated on cytidines by DNA methylases (DNMTs)to generate 5-methylcytidine (5-mC), a potent epigenetics marker and regulator of gene expression. The reverse reaction (cytidine demethylation) starts with its oxidation to hydroxymethyl- (5-hmC), formyl- (5-fC), and carboxy- (5-caC) cytidine. Several enzymes, including the Tet family of proteins have been implicated in cytidine demethylation.

UOM: 1 * 100 µl

Sale

Artikel-Nr: (BOSSBS-9450R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-9450R-A555

Beschreibung: Cytidine is a nucleoside formed by a cytosine attached to a ribose ring via a beta-N1-glycosidic bond. DNA is methylated on cytidines by DNA methylases (DNMTs)to generate 5-methylcytidine (5-mC), a potent epigenetics marker and regulator of gene expression. The reverse reaction (cytidine demethylation) starts with its oxidation to hydroxymethyl- (5-hmC), formyl- (5-fC), and carboxy- (5-caC) cytidine. Several enzymes, including the Tet family of proteins have been implicated in cytidine demethylation.

UOM: 1 * 100 µl

Sale