Sie suchten nach: Bioss

Artikel-Nr: (BOSSBS-3195R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3195R

Beschreibung: Anti-IRF3 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-12346R-A647)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-12346R-A647

Beschreibung: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-13706R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-13706R

Beschreibung: The calcium-activated chloride channel (CLCA) protein family, which includes the human homologs CLCA1 and CLCA2, display distinct tissue distribution patterns. CLCA1 is expressed as a precursor protein that is processed into two cell surface associated subunits and a group of proteins. CLCA1 is upregulated by interleukin-9 and regulates the expression of mucins. CLCA1 may provide a therapeutic target to control mucus overproduction in airway disease patients with cystic fibrosis. CLCA2 expression is downregulated in breast cancer, therefore CLCA2 is thought to act as a tumor suppressor in normal cells. CLCA3 (known as Clca3 in mouse) is a structurally divergent member of the CLCA family that does not function as a channel protein. CLCA4 is a CLCA member that is expressed in human rectal mucosa, CLCA5 shows strong expression in eye and spleen, and CLCA6 is primarily expressed in intestine and stomach.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4208R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-4208R

Beschreibung: Cullin 1 may be involved in the degradation of positive cell cycle regulators (for example G1 cyclins in yeast). Human cullin 1 forms a complex with Skp1 and the F box protein Skp2, which is thought to play a role in the ubiquitination of G1 regulatory proteins, as its homolog does in yeast.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-15401R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15401R

Beschreibung: H2BFWT (H2B histone family member W testis-specific) is a 175 amino acid nuclear membrane histone that belongs to the histone H2B family. In contrast to most H2B histones, H2BFWT does not contain the conserved C-terminal residue involved in monoubiquitination, but is structurally indistinguishable from conventional H2B histones. Also varying from other H2B histones, H2BFWT does not participate in the recruitment of chromosome condensation factors or in the assembly of mitotic chromsomes. Expressed in testis, H2BFWT is present in sperm cells and may be essential to telomere function.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4211R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-4211R

Beschreibung: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4. The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539).

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-15399R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15399R

Beschreibung: Anti-H2A1J Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1460R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1460R

Beschreibung: Anti-IL23R Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1488R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1488R

Beschreibung: Anti-BCL2L11 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-12380R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-12380R

Beschreibung: Wnt-induced secreted protein (WISP)-1, WISP-2 and WISP-3 are members of the CCN family of growth factors, which include connective tissue growth factor (CTGF) and Cyr61. WISP-1, WISP-2 and WISP-3 share significant sequence similarity, including four conserved cysteine-rich domains, and they are believed to function as dimers in their active forms. WISP-1 expression is observed in various tissues including adult heart, kidney and spleen, while WISP-2 expression predominates in skeletal muscle, colon and ovary. Both WISP-1 and WISP-2 are upregulated in cells transformed with the proto-oncogene Wnt-1, and they are also more highly expressed in human colon tumors, suggesting that these proteins may participate in tumor development. WISP-3 is involved in normal post-natal skeletal growth, and it is also implicated in the development of the autosomal recessive skeletal disorder progressive pseudorheumatoid dysplasia, which affects cartilage homeostasis by disrupting the growth of chondrocyte and normal cell columnar organization.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-13375R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-13375R

Beschreibung: The GLIPR1 family consists of three core members, designated GLIPR1, GLIPR1L1 (GLIPR1-like protein 1) and GLIPR1L2, which form a distinct subgroup within the cysteine-rich secretory protein (CRISP), antigen 5 and pathogenesis-related 1 (CAP) superfamily. Each member of the CAP superfamily has a conserved N-terminal CAP domain and a distinct C-terminal extension. CAP superfamily proteins are hypothesized to have roles in immunity, cell adhesion, carcinogenesis and male fertility. GLIPR1L1 is a 242 amino acid secreted protein. Highly expressed in testis, GLIPR1L1 exists as two isoforms produced by alternative splicing events. GLIPR1L1 is encoded by a gene that maps to human chromosome 12q21.1 and mouse chromosome 10 D2.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-13371R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-13371R

Beschreibung: Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors that mediate protein passage through the nuclear pore complex (NPC). Gle1, also known as GLE1L, is a 698 amino acid protein that localizes to both the nucleus and the cytoplasm and belongs to the Gle1 family. Expressed as two alternatively spliced isoforms, Gle1 associates with the NPC and is required for the transport of poly(A)-containing mRNAs from the nucleus to the cytoplasm. Defects in the gene encoding Gle1 are the cause of lethal congenital contracture syndrome type 1 (LCCS1) and lethal arthrogryposis with anterior horn cell disease (LAAHD), the former of which is characterized by early fetal hydrops and akinesia, micrognatia, pulmonary hypoplasia, pterygia and prenatal death, while the latter is associated with respiratory failure.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-13376R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-13376R

Beschreibung: Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3829R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3829R

Beschreibung: Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. SDH is expressed almost ubiquitously in all mammalian tissues. The enzyme has attracted considerable interest due to its implication in the development of diabetic complications as the polyol pathway is particularly active in hyperglycemic states. Although SORD is closely related to the class I long-chain alcohol dehydrogenases, it differs in substrate specificity, catalyzing polyols such as sorbitol and xylitol but having no activity towards primary alcohols.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-13532R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-13532R

Beschreibung: G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. G protein-coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR34 is a 381 amino acid protein belonging to the G-protein coupled receptor 1 family. Widely expressed, GPR34 is localized to the cell membrane.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-2391R)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-2391R

Beschreibung: Zinc is an essential cofactor for more than 50 classes of enzymes and is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, plus the control of gene transcription, growth, development, and differentiation. Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the cytosol from both the extracellular environment and from intracellular storage compartments.

UOM: 1 * 100 µl

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