Sie suchten nach: Arabinofuranosyl-guanine+hydrate

Artikel-Nr: (BOSSBS-5807R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-5807R-A750

Beschreibung: ELMO1 is involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. ELMO1 acts in association with DOCK1 and CRK and was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. It is belived to enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10035R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-10035R-A750

Beschreibung: catalyses the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10035R-A680)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-10035R-A680

Beschreibung: catalyses the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10035R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-10035R-HRP

Beschreibung: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-11582R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11582R-A555

Beschreibung: Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-12866R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-12866R-HRP

Beschreibung: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-11804R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11804R-HRP

Beschreibung: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects golgi structure, and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-13470R-A680)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-13470R-A680

Beschreibung: Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. Transducin is a guanine nucleotide-binding protein found specifically in rod outer segments, where it mediates activation by rhodopsin of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase. Transducin is also referred to as GMPase. GNGT1 encodes the gamma subunit of transducin (Hurley et al., 1984 [PubMed 6438626]; Scherer et al., 1996 [PubMed 8661128]).[supplied by OMIM, Mar 2008].

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-11582R-A647)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11582R-A647

Beschreibung: Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-11582R-A680)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11582R-A680

Beschreibung: Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1894R-A488)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1894R-A488

Beschreibung: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4109R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-4109R-A555

Beschreibung: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4109R-A488)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-4109R-A488

Beschreibung: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7768R-A488)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7768R-A488

Beschreibung: Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7768R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7768R-HRP

Beschreibung: Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7144R-CY5.5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7144R-CY5.5

Beschreibung: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].

UOM: 1 * 100 µl

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