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Product Image-ENZOALX420035M025

Apoptosis activator 2 ≥98% (durch NMR)

Lieferant: ENZO LIFE SCIENCES
Beschreibung: Apoptosis inducer.

New Product

Image Unavailable-A1895-5G

Aurintricarbonsäure ≥85%, Pulver, geeigneter Qualität zur Titration, Sigma-Aldrich®

Lieferant: SIGMA ALDRICH MICROSCOPY
Beschreibung: Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca²⁺ -impermeable GluR2 receptors and inhibits calpain, a Ca²⁺ -activated protease that is activated during apoptosis.

Product Image-30060.

Apoptosis and necrosis quantitation kits

Lieferant: Biotium
Beschreibung: Apoptosis and necrosis are two processes by which cells die. Apoptosis is an active, regulated disassembly of the cell from within. During apoptosis, phosphatidylserine is translocated from the inner to the outer surface of the cell, allowing the dying cell to be engulfed by phagocytic cells. Annexin V is a 35 kD Ca2+-dependent phospholipid binding protein with a high affinity for phosphatidylserine.

Image Unavailable-BOSSBS-0059R-CY5.5

Anti-APAF1 Rabbit Polyclonal Antibody (Cy5.5®)

Artikel-Nr: (BOSSBS-0059R-CY5.5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-0059R-CY5.5
Beschreibung: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0059R-FITC

Anti-APAF1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Artikel-Nr: (BOSSBS-0059R-FITC)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-0059R-FITC
Beschreibung: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0059R-A488

Anti-APAF1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Artikel-Nr: (BOSSBS-0059R-A488)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-0059R-A488
Beschreibung: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
UOM: 1 * 100 µl
Image Unavailable-A36883-25G

Aluminon ACS, Sigma-Aldrich®

Lieferant: SIGMA ALDRICH MICROSCOPY
Beschreibung: Reagent for aluminium. Aurintricarboxylic acid readily polymerises in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca²⁺ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca²⁺-activated protease that is activated during apoptosis.

Image Unavailable-BOSSBS-0738R-A750

Anti-Livin Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Artikel-Nr: (BOSSBS-0738R-A750)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-0738R-A750
Beschreibung: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8869R-FITC

Anti-ITPR1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Artikel-Nr: (BOSSBS-8869R-FITC)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-8869R-FITC
Beschreibung: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0738R-FITC

Anti-BIRC7 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Artikel-Nr: (BOSSBS-0738R-FITC)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-0738R-FITC
Beschreibung: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0738R-A555

Anti-BIRC7 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Artikel-Nr: (BOSSBS-0738R-A555)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-0738R-A555
Beschreibung: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0050R

Anti-CASP9 Rabbit Polyclonal Antibody

Artikel-Nr: (BOSSBS-0050R)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-0050R
Beschreibung: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5241R-CY7

Anti-CASP9 Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-5241R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5241R-CY7
Beschreibung: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5241R-CY5

Anti-CASP9 Rabbit Polyclonal Antibody (Cy5®)

Artikel-Nr: (BOSSBS-5241R-CY5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-5241R-CY5
Beschreibung: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0050R-CY5

Anti-CASP9 Rabbit Polyclonal Antibody (Cy5®)

Artikel-Nr: (BOSSBS-0050R-CY5)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-0050R-CY5
Beschreibung: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1870R-CY7

Anti-PEG3 Rabbit Polyclonal Antibody (Cy7®)

Artikel-Nr: (BOSSBS-1870R-CY7)
Lieferant: Bioss
Hersteller Artikel Nummer : BS-1870R-CY7
Beschreibung: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.
UOM: 1 * 100 µl
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