Sie suchten nach: 8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carbaldehyde

44'459 results were found

Suchergebnis einschränken: Sortieren nach

Sort Results

Listenansicht Easy View

Vergleichen(0) Entfernen

Bewerten Sie das Suchergebnis

8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carbaldehyde

Lieferant: Apollo Scientific

Beschreibung: 8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carbaldehyde

WYE-125132 ≥99% (durch HPLC)

Lieferant: ENZO LIFE SCIENCES

Beschreibung: Highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Antiproliferative.

New Product

WYE-125132 ≥98%, kristalliner Feststoff

Lieferant: Cayman Chemical

Beschreibung: WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.