Thapsigargin ≥99% (durch HPLC)
Lieferant: ENZO LIFE SCIENCES AG
ATPase inhibitor
Cell permeable tumor promoter. Induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the (sarco)endoplasmatic reticulum Ca2+-ATPase (SERCA) (IC50=30nM). Inhibition of SERCA reveals a significant change in intracellular Ca2+ homeostasis and pH regulation in tumor cells. May be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of PKC activation. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Induces apoptosis. Stimulates nitric oxide (NO) production, contributing to hepatocyte apoptosis.
Formel:
C₃₄H₅₀O₁₂ MW: 650,762 g/mol |
MDL Number:
MFCD00083511 CAS-Nummer: 67526-95-8 |
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