Manoalide ≥98% (durch TLC)

Lieferant: ENZO LIFE SCIENCES AG

ENZOBMLEI1770001EA 272 CHF
ENZOBMLEI1770001
Manoalide ≥98% (durch TLC)
Manoalide

Phospholipase inhibitor


Marine sesterterpenoid. Irreversibly inhibits human synovial phospholipase A2 (PLA2, IC50=0.02-0.2µM depending on substrate) as well as bee (IC50=0.05µM) and cobra venom (IC50=2µM) PLA2 by covalently modifying lysine residues. Inhibits human recombinant sPLA2 (IC50=4.7µM) selectively over cPLA2. Also inhibits phospholipase C (PLC, IC50=1.5µM) and Ca2+ channels. Inhibits superoxide generation in polymorphonuclear leukocytes. Inhibits the release of arachidonate in cultured mouse peritoneal macrophages and in a mouse in vivo model. Has anti-inflammatory and analgesic properties. Shows strong quorum sensing antagonism.

Formel: C₂₅H₃₆O₅
MW: 416,558 g/mol
MDL Number: MFCD00153826
CAS-Nummer: 75088-80-1
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