Sulpho-SMCC (3-Sulpho-N-succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt), Premium Grade, Pierce™
Lieferant: Thermo Fisher Scientific
|
Achtung
|
Thermo Scientific Pierce Premium Grade Sulfo-SMCC is our highest quality formulation of amine-to-sulfhydryl crosslinker, specially characterized for applications where product integrity and risk minimization are paramount.
- Sulfo-SMCC—a water-soluble amine-to-sulfhydryl crosslinker with a stabilizing cyclohexane spacer arm
- High quality—identity and purity confirmed by several tests, including quantitative NMR
- Product integrity—enhanced level of testing and characterization compared to standard grade
- Lot retention—ample supply of past lots retained to ensure future process testing
- Change management—Change Control Notification (CCN) service
- Consistent manufacture—batch-specific manufacturing documentation review
Compared to the standard grade product, Premium Grade Sulfo-SMCC provides more clearly defined quality and product support by including (a) increased analytical testing and product characterization, (b) greater batch-specific information and quality assurance review, (c) extensive lot sample retention and (d) change control notification. Sulfo-SMCC is a water-soluble, non-cleavable and membrane-impermeable amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 angstroms). NHS esters react with primary amines at pH 7-9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. The maleimide groups of Sulfo-SMCC are unusually stable up to pH 7.5 because of the cyclohexane bridge in the spacer arm. Because it contains the hydrophilic sulfonyl moiety, Sulfo-SMCC is soluble up to nearly 10 mM in water and many commonly used buffers, thus avoiding the use of organic solvents which may perturb protein structure.
Bitte beachten For Research Use Only. Not for use in diagnostic procedures.
|
Formel:
C₁₆H₁₈N₂O₉S MW: 436,37 g/mol Lager Temperatur: Gefrierschrank |
MDL Number:
MFCD00054978 CAS-Nummer: 92921-24-9 |
Spezifikation Testergebnisse
| Product Line | Pierce™ |
| Labeling Method | Chemical Labeling |
| Crosslinker Type | Heterobifunctional |
| Reactive Moiety | Maleimide, Sulfo-NHS Ester |
| Spacer | Short |
| Form | Powder |
| Quantity | 100 mg/1 g |
| Type | Crosslinker |
| Solubility | Water |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...