Anti-CSF1R rat antibody (PE (Phycoerythrin)) [clone: AFS98]

Lieferant: Tonbo Biosciences
50-1152-U025 50-1152-U100
50-1152-U025EA 94.1 CHF
50-1152-U025 50-1152-U100
Anti-CSF1R rat antibody (PE (Phycoerythrin)) [clone: AFS98]
Antikörper
The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signalling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellularMore Product Information
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