Toluol-α-sulfonylfluorid, weiße bis weißgraue nadelähnliche Kristalle

Lieferant: ICN Biomedicals
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Synonyms: α-ToluolsulfonsäurefluoridPMSFα-ToluolsulfonylfluoridPhenylmethansulfonylfluoridPhenylmethylsulfonylfluoridPhenylmethansulfonsäurefluorid

ICNA0219538180EA 1370 CHF
ICNA0219538180 ICNA0219538125 ICNA02195381.2 ICNA0219538105 ICNA0219538101
Toluol-α-sulfonylfluorid, weiße bis weißgraue nadelähnliche Kristalle
Toluol-α-sulfonylfluorid

Phenylmethylsulfonyl fluoride is an irreversible inhibitor of serine proteases - inhibits trypsin, chymotrypsin and protease. Inhibits mammalian acetyl cholinesterase, but not those from fish sources.


  • Presentation: White to off white needle crystals
  • Causes sulfonylation of the active-site serine residue
  • A less toxic substitute for the extremely toxic diisopropylfluorophosphate


Phenylmethylsulfonyl fluoride inhibits serine proteases such as trypsin and chymotrypsin. Also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase.
Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.


Soluble in methanol and ethanol

Formel: C₇H₇FO₂S
MW: 174,2 g/mol
Melting Pt: 89…99 °C
Lager Temperatur: Kühlschrank
MDL Number: MFCD00007424
CAS-Nummer: 329-98-6
EINECS: 206-350-2
UN: 2928
ADR: 6.1,II

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