Thapsigargin ≥97% (durch TLC), farbloser Feststoff, Millipore®
Lieferant: Merck Millipore Calbiochem
586005-1EA
367
CHF
586005-1
Thapsigargin ≥97% (durch TLC), farbloser Feststoff, Millipore®
Thapsigargin
Thapsigargin is a cell-permeable tumour-promoting sesquiterpene lactone that releases Ca²⁺ by inhibiting endoplasmic reticular Ca²⁺-ATPase.
- Colourless solid
It does not increase inositol phosphates and has no significant effect on protein kinase C. It increases Ca²⁺-dependent Na⁺ influx in human platelets in a dose-dependent manner. Ii induces apoptosis in rat thymocytes and in human hepatoma cells and in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.
Formel:
C₃₄H₅₀O₁₂ MW: 650,762 g/mol Lager Temperatur: Gefrierschrank |
MDL Number:
MFCD00083511 CAS-Nummer: 67526-95-8 |
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