Y-27632, Millipore®

Lieferant: Merck Millipore Calbiochem

688000-1 688000-5 688000-10 688000-100MG
688000-1EA 569 CHF
688000-1 688000-5 688000-10 688000-100MG
Y-27632, Millipore®
Y-27632

A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nm for p160ROCK). Also inhibits ROCK-II with equal potency. Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction.


  • Inhibition is competitive with respect to ATP
  • Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK
  • Pretreatment with Y-27632 reduces the risk of lung injury in rat models of sepsis
  • Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µm)


Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mm (500 µg/296 µl) solution of Y-27632 in H2O and a 10 mm solution in DMSO are also available.

Formel: C₁₄H₂₁N₃O
MDL Number: MFCD03093855
CAS-Nummer: 146986-50-7

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