Y-27632, Millipore®
Lieferant: Merck Millipore Calbiochem
688000-10EA
2970
CHF
688000-10
688000-5
688000-100MG
688000-1
Y-27632, Millipore®
trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nm for p160ROCK). Also inhibits ROCK-II with equal potency. Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction.
- Inhibition is competitive with respect to ATP
- Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK
- Pretreatment with Y-27632 reduces the risk of lung injury in rat models of sepsis
- Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µm)
Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mm (500 µg/296 µl) solution of Y-27632 in H2O and a 10 mm solution in DMSO are also available.
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Formel:
C₁₄H₂₁N₃O MW: 247,34 g/mol |
MDL Number:
MFCD03093855 CAS-Nummer: 146986-50-7 |
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