Anti-CD59 Rat Monoclonal Antibody (Purified) [clone: MACIF/1193]

Lieferant: Biotium
BNUB1193-500 BNUB1193-100
BNUB1193-500EA 613 CHF
BNUB1193-500 BNUB1193-100
Anti-CD59 Rat Monoclonal Antibody (Purified) [clone: MACIF/1193]
Antikörper
This antibody reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). It is useful for study on GPI-anchored proteins, PNH and CD59 functions.

Type: Primary
Antigen: CD59
Clonality: Monoclonal
Clone: MACIF/1193
Conjugation: Purified
Epitope:
Host: Rat
Isotype: IgM kappa
Reactivity: Human
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