Anti-NUMA1 Mouse Monoclonal Antibody (Purified) [clone: A73-B/D12]

Lieferant: Biotium
BNUB0939-500 BNUB0939-100
BNUB0939-500EA 613 CHF
BNUB0939-500 BNUB0939-100
Anti-NUMA1 Mouse Monoclonal Antibody (Purified) [clone: A73-B/D12]
Antikörper
Recognizes a phosphorylated protein of 228 kDa, identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis, it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase, the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200 kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.

Type: Primary
Antigen: NUMA1
Clonality: Monoclonal
Clone: A73-B/D12
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgM kappa
Reactivity: Human
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